Xenoport, Inc.

Arbor Pharmaceuticals, LLC

Glaxo Group Limited

Protagonist Therapeutics, Inc.

Mark A. Gallop

Suresh K. Manthati

Thu Phan

Maria Ludwikow

Stephen P. Raillard

Xuedong Dai

Fenmei Yao

Randall A. Scheuerman

Ge Peng

Seema Bhat

Suresh Kumar Manthati

Stephen P Raillard

Randall A Scheuerman

Mark A Gallop

Sami Karaborni

Wei Chen

Seema Rani Bhat

Maria J Ludwikow

Cindy X Zhou

Sudhir Joshi

Jia-Ning Xiang

Mark Quang Nguyen

Tono Estrada

Qunying Dai

Hao Yin

Adam Mann

Peng Liu

Dinesh Vinoobhai Patel

Kenneth C Cundy

David Juergen Wustrow

Ashok Bhandari

Sampath-Kumar Anandan

Mukund M Mehrotra

Pharmaceutical compositions and dosage forms of dimethyl fumarate containing low levels of certain impurities are disclosed.

Pharmaceutical compositions of dimethyl fumarate

Pharmaceutical compositions and dosage forms of (N,N-diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate and/or methyl 4-morpholin-4-ylbutyl (2E)but-2-ene-1,4-dioate, containing low levels of certain impurities are disclosed.

Pharmaceutical compositions of fumaric acid esters

The present invention provides methods of making &#x3b1;4&#x3b2;7 peptide monomer and dimer antagonists. Methods of the present invention include solid phase and solution phase methods, as well as synthesis via condensation of smaller peptide fragments. Methods of the present invention further include methods directed to the synthesis of peptides comprising one or more penicillamine residues.

Methods for synthesizing &#x3b1;4&#x3b2;7 peptide antagonists

Methods of synthesizing a levodopa ester prodrug, salts thereof, and synthetic intermediates thereof are disclosed.

Methods of synthesizing a levodopa ester prodrug

Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof

Methods of making monomethyl fumarate, which can then also be used in methods of making prodrugs of monomethyl fumarate, are disclosed. Monomethyl fumarate and prodrugs of monomethyl fumarate are useful for treating neurodegenerative, inflammatory, and autoimmune diseases including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis.

Method of making monomethyl fumarate

Crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxyl)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate and crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxyl)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid hemihydrate, pharmaceutical compositions comprising such compounds, methods of making and methods of using the same are disclosed.

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Crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate and crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid hemihydrate, pharmaceutical compositions comprising such compounds, methods of making and methods of using the same are disclosed.

Morpholinoalkyl fumarates, pharmaceutical compositions comprising the morpholinoalkyl fumarates, and methods of using morpholinoalkyl fumarates and pharmaceutical compositions for treating neurodegenerative, inflammatory, and autoimmune disorders including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are disclosed.

Morpholinoalkyl fumarate compounds, pharmaceutical compositions, and methods of use

Growing community of inventors

Sunnyvale, CA, United States of America

Suresh Kumar Manthati