Schering Corporation

Surendra A Sangekar

Winston A Vadino

Ping I Lee

Eugenio A Cefali

Amin Nomeir

Molecular dispersion composition with enhanced bioavailability

A pharmaceutical composition in the form of a substantially amorphous solid solution comprising an antifungal compound of the formula I: ##STR1## wherein: X is F; and R.sub.1 is ##STR2## or an ester or ether of said compound of Formula I; and a soluble or insoluble polymer such as: povidone or crospovidone, wherein the ratio of said compound to said polymer is about 1:3 to about 1:6 is disclosed.

Solid solution of an antifungal agent with enhanced bioavailability

Oral antifungal composition

Antifungal composition with enhanced bioavailability

A long acting diltiazem formulation is disclosed that comprises more than 35 percent by weight of a swellable hydrophilic polymer. Release rate is also controlled by the application of diffusion controlled membrane to the matrix tablet containing swellable hydrophilic polymers. The diffusion rate through the membrane depends upon the composition or ratio of hydrophilic to hydrophobic coating agent.

Long acting diltiazem formulation

An immediate release diltiazem tablet is disclosed that exhibits an unexpectedly rapid bioavailability profile when the active ingredient is diltiazem.

Immediate release diltiazem formulation

A sustained release dosage form of labetalol hydrochloride is disclosed comprising the active ingredient in a polymeric matrix of hydroxypropylmethylcellulose and polyvinylpyrrolidone and a pharmaceutically acceptable organic acid.

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Union, NJ, United States of America

Surendra A Sangekar