Auburn University

Suram T Pathirana

Vitaly J Vodyanoy

Bryan A Chin

William Charles Neely

James Barbaree

Timothy D Braden

Alexandre M Samoylov

Tatiana I Samoylova

Compositions and methods for the reversible preservation of biological samples are provided. The compositions include natural polymers such as pullulan or acacia gum, including derivations and modifications thereof, which are usefull as a reversible preservation solution. A method is provided for using pullulan or Acacia Gum to isolate and reversibly preserve a biological specimen in a dormant state at room temperature for an extended period with minimal damage to the specimen. The compositions and methods disclosed may also be used to create reversibly preserved biological specimens and biological receptors for use in biosensors.

Use of pullulan to isolate and preserve biological material

Compositions and methods for the reversible preservation of biological samples are provided. The compositions includeGum, including derivations and modifications thereof which are useful as a reversible preservation solution. A method is provided for usingGum to isolate and reversibly preserve a biological specimen in a dormant state at room temperature for an extended period with minimal damage to the specimen. The compositions and methods disclosed may also be used to create reversibly preserved biological specimens and biological receptors for use in biosensors.

Use of acacia gum to isolate and preserve a biological receptor on a biosensor

Methods and compositions for evaluating the affinity of one or more ligands of interest are provided. In particular, a ligand sensor device (LSD) comprising a sensor coupled to a peptide of interest is provided. Assays using the LSD allow detection of ligand-peptide interactions directly in tissue samples and thus provide an in vitro assay to characterize peptide ligands. The LSD and assays find particular use in characterizing cell-specific peptides isolated from in vivo screening in animals to determine their suitability for use in human therapy.

Ligand sensor devices and uses thereof

Use of Acacia Gum to isolate and preserve biological material

Growing community of inventors

Sunnyvale, CA, United States of America

Suram T Pathirana