Council of Scientific and Industrial Research

Suprabhat Ray

Atul Kumar

Girish Kumar Jain

Man Mohan Singh

Sangita

Puvvada Sri Ramanchandra Murthy

Nitya Anand

Anil Kumar Rastogi

Anju Puri

Ved P Kamboj

Mohammad Salman

Farhar Rivizvi

Geetika Bhatia

Ramaesh Chander

Rehan Ahmad

Priti Tewari

Arivend Srivastava

Reema Rastogi

Devdutt Chaturvedi

Novel mercaptophenyl naphthyl methane compounds, their pharmaceutically acceptable salts and compositions comprised thereof are useful for the prevention or treatment of various medical indications associated with estrogen dependent diseases or syndromes related to osteoporosis, bone loss, bone formation, cardiovascular disorders, neurodegenerative disorders, menopausal disorders, physiological disorders, diabetes disorders, prostatic carcinoma, cancer of breast, cancer of uterus, cancer of the cervix and cancer of the colon, threatened or habitual abortion, obesity, ovarian development or function, post-partum lactation and depression.

Mercaptophenyl naphthyl methane compounds and synthesis thereof

The present invention relates to compounds of the formula I in which substituents Rand Rare arranged in trans-configuration: wherein: wherein Y is chosen from NHR, NR, NHCOR, NHSOR, CONHR, CONR, CONR, COOH, COOR, SOR, SOR, SONHR, SONR, a C3-C7 heterocyclic ring, saturated or unsaturated, containing one or two heteroatoms independently selected from the group consisting of O, S and N, optionally being substituted with 1 to 3 substituents independently selected from the group comprising H, OH, halogen, nitro, cyano, SH, SR, trihalo-C1-C6-alkyl, C1-C6-alkyl and C1-C6-alkoxy, preferably NHR, NR, or a nitrogen heterocycle, wherein Ris as defined above, and the esters, ethers, and salts of the compounds of formula I, optionally along pharmaceutically acceptable excipients, a process for the preparation of the same, and a method of preventing and/or treating estrogen-related disease conditions in a subject using compounds of formula 1, or its salts, optionally along with pharmaceutically acceptable excipients.

(3R, 4R)-trans-3, 4-diarylchroman derivatives and a method for the prevention and/or treatment of estrogen dependent diseases

This invention relates to novel {overscore (&#x3c9;)}-substituted-naphthyloxy-amino alkanes, their preparation and use as antihyperglycemic agents and for the treatment and prevention of cardiovascular disorders (CVS) such as lipid lowering effects.

Alpha-substituted naphthyloxy omega-substituted alky/aryl amino-substituted alkane derivatives as agent for treatment or prophylaxis of diabetes and related metabolic disorders

The laevo and dextro forms of dl-3,4-trans-2,2-disubstituted-3,4-diarylchromans and similar derivatives thereof have substantially double the post-coital anti-fertility activity of the known racemic compound. The resolution of such known compound into the l- and d-isomeric forms may be carried out using di-p-toluoyl-l-tartaric acid monohydrate or di-p-toluoyl-d-tartaric acid.

Preparation of l- and d-isomers of

Growing community of inventors

Lucknow, India

Suprabhat Ray