Technical Institute of Physics and Chemistry, Cas

Beijing Cas Microneedle Technology Ltd.

Suohui Zhang

Yunhua Gao

Han Liu

Guozhong Yang

Zequan Zhou

Aguo Cheng

Meilin He

A nanonization method for cannabidiol (CBD) includes following steps: the CBD is dissolved in a good solvent to obtain a CBD-good solvent solution, the CBD-good solvent solution is added to aqueous solution of a stabilizer to obtain mixed solution, the mixed solution is ultrasonicated followed by removing the good solvent by rotary evaporation from the mixed solution to obtain a nanosized CBD suspension. The stabilizer includes one or more selected from the group consisting of poloxamer, tween, polyoxyethylene alkyl ether, polyvinyl pyrrolidone, hydroxypropyl methyl cellulose and carboxymethyl chitosan. Particle size of the CBD is reduced in the nanonization method for the CBD through the nanonization of insoluble drugs to obtain the nanosized CBD suspension. In the nanosized CBD suspension, nanosized CBD has high solid content. The nanonization method for the CBD achieves solubilization of the CBD.

Dissolving microneedle containing cannabidiol suspension and preparation method thereof

An insoluble transdermal microneedle patch, includes microneedles and a backing. The microneedles include bases and needlepoints located on the base, and materials made for the microneedles include crosslinked sodium alginate. The backing is connected with the bases, and parts of the backing corresponding to the needlepoints are hollow portions. The microneedle patch can act in the skin for a long time, during it is used for transdermal delivery, drugs can enter skin micropores to be absorbed into a body through pores formed after swelled microneedles acting on the skin absorbs water, thereby increasing a bioavailability of the drugs during the transdermal delivery. After drug administration end, the microneedles are completely removed without increasing a metabolic burden in the body, soluble materials are prevented from being accumulated in the body, and the microneedles have good biological safety. A preparation method of the insoluble transdermal microneedle patch and application thereof are provided.

Insoluble transdermal microneedle patch, and preparation method therefor and application thereof

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Beijing, China

Suohui Zhang