The University of Oklahoma

Sunny Po

Benjamin J Scherlag

David E Albert

Kenneth J Dormer

Stavros Stavrakis

Paul Garabelli

Carey N Pope

Methods and systems for alleviating disorders and complications associated with autonomic nervous system dysfunction. The approach generally includes measuring heart rate signals from a subject to measure heart rate variability and determine a heart rate variability threshold, determining that the subject is experiencing autonomic nervous system dysfunction, and alerting the subject to stimulate the auricular branch of the vagus nerve with an ear device.

System and method for treating autonomic nervous system dysfunctions

Compositions and methods for treating various cardiovascular disorders include targeted delivery of glutamate for impairing a targeted portion of the autonomic nervous system (ANS). Targeted delivery may be via direct injection into the targeted portion of the ANS or via vascular injection of magnetically-targetable nanoparticles.

Glutamate treatment of cardiovascular disorders

Methods for treating various cardiovascular disorders include targeted delivery of calcium ions for permanently impairing a portion of the autonomic nervous system (ANS). Targeted delivery may be via magnetically-targetable nanoparticles.

Treatment of cardiovascular disorders with targeted nanoparticles

The present disclosure describes a method for targeted delivery of permanently-acting or temporarily-acting neurotoxins, neurosuppressants, or other compounds having a neurologic effect to specific locations of the heart, including for example, but not limited to, nodes of the cardiac autonomic nervous system such as the atrial ganglionated plexi (GP). Chemical ablation of the atrial GP as described herein via magnetically-targeted magnetically-susceptible nanoparticles can effectively suppress GP activity and atrial fibrillation related, thereto without permanent damage to either myocardium or intrinsic CANS.

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Edmond, OK, United States of America

Sunny Po