Ambit Biosciences Corporation

Recurium IP Holdings, LLC

Vertex Pharmaceuticals, Inc.

Sunny Abraham

Qi Chao

Mark W Holladay

Eduardo Setti

Kevin Duane Bunker

Peter Qinhua Huang

Chad Daniel Hopkins

Shripad S Bhagwat

Martin W Rowbottom

Joseph Robert Pinchman

Kelly G Sprankle

Andiliy Gokching Lai

Brian T Campbell

Deborah Helen Slee

Raffaella Faraoni

Gang Liu

Michael J Hadd

Mehmet Kahraman

Rakesh Kumar Sit

Brant Clayton Boren

Daniel Lee Severance

Aditya Krishnan Unni

Mark Thomas Miller

Jinglan Zhou

Sara Sabina Hadida Ruah

Jason McCartney

Corey Don Anderson

Vijayalaksmi Arumugam

Peter Grootenhuis

Paul Krenitsky

Thomas Cleveland

Sunil Paliwal

Bryan A Frieman

Alina Silina

Johnny Uy

Jeremy J Clemens

Sayee Gajanan Hegde

Benjamin Pratt

Vito Melillo

Hui Liu

Alexander Russell Abela

Jaclyn Chau

Yoshihiro Ishihara

Timothy A Dwight

Sobhana Babu Boga

Compound (I), deuterated derivatives, and pharmaceutically acceptable salts of any of the foregoing are disclosed. Methods of treating cystic fibrosis using these compounds are also disclosed.

Cystic fibrosis transmembrane conductance regulator modulating agents

Disclosed herein are methods for preparing tertiary alcohols from an optionally substituted phenyl ketone or an optionally substituted pyridinyl ketone that includes the use of a chiral ligand and boron trifluoride diethyl etherate. Tertiary alcohols can be used to prepare synthetic versions of natural products and/or pharmaceuticals.

Chiral synthesis of a tertiary alcohol

Disclosed herein are nitrogen-containing bicyclic compounds of Formula (I), including pharmaceutically acceptable salts thereof, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.

EGFR inhibitor compounds

Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.

Substituted 1,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-ones

Disclosed herein are nitrogen-containing bicyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.

Disclosed herein are spirocyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.

Spirocyclic compounds

Compounds, compositions and methods are provided for modulating the activity of RAF kinases, including BRAF kinase and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by RAF kinases.

RAF kinase modulator compounds and methods of use thereof

Compositions of 1-(3-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-3-(5-(1,1,1, -trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea are provided for modulating the activity of RAF kinases, including BRAF kinase and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by RAF kinases.

Provided herein are quinazoline compounds of formula (I):  The compounds are useful for treatment of JAK kinase mediated diseases, including JAK2 kinase-, JAK3 kinase- or TYK2 kinase-mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.

JAK kinase modulating compounds and methods of use thereof

Compounds according to formula (I), compositions and methods are provided for modulating the activity of RAF kinases, including BRAF kinase and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by RAF kinases. Formula (I): or a pharmaceutically acceptable salt, solvate, clathrate of hydrate thereof, wherein X is O or S(O); Ris O or S. 

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San Diego, CA, United States of America

Sunny Abraham