Merck Sharp + Dohme Corp.

Sunita Malkani

Lihu Yang

Changyou Zhou

Haifeng Tang

Songnian Lin

Min Ge

Eric Dean Cline

Bicyclic compounds containing a phenyl or pyridyl ring fused to a cycloalkyl or heterocyclic ring, to which is attached a 5-membered heterocyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

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Lincoln Park, NJ, United States of America

Sunita Malkani