Polytherics Limited

M. L. Laboratories Plc

Sunil Shaunak

Stephen James Brocchini

Antony Robert Godwin

Elisa Pedone

Ji-Won Choi

Donald Selwyn Davies

Nigel John Gooderham

Robert John Edwards

Jin-Won Choi

Novel biologically active compounds of the general formula (I) in which one of X and X' represents a polymer, and the other represents a hydrogen atom; each Q independently represents a linking group; W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety; or, if X&#x2032; represents a polymer, X-Q-W&#x2014; together may represent an electron withdrawing group; and in addition, if X represents a polymer, X&#x2032; and electron withdrawing group W together with the interjacent atoms may form a ring; each of Zand Zindependently represents a group derived from a biological molecule, each of which is linked to A and B via an amine group; or Zand Ztogether represent a single group derived from a biological molecule which is linked to A and B via two amine groups; A is a Calkylene or alkenylene chain; and B is a bond or a Calkylene or alkenylene chain; are formed by conjugating a suitable polymer to a suitable biologically active molecule via amine groups in said molecule, preferably via a disulphide bridge. 

Conjugated biological molecules and their preparation

Novel biologically active compounds of the general formula (I) in which one of X and X' represents a polymer, and the other represents a hydrogen atom; each Q independently represents a linking group; W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety; or, if X&#x2032; represents a polymer, X-Q-W&#x2014; together may represent an electron withdrawing group; and in addition, if X represents a polymer, X&#x2032; and electron withdrawing group W together with the interjacent atoms may form a ring; each of Zand Zindependently represents a group derived from a biological molecule, each of which is linked to A and B via a nucleophilic moiety; or Zand Ztogether represent a single group derived from a biological molecule which is linked to A and B via two nucleophilic moieties; A is a Calkylene or alkenylene chain; and B is a bond or a Calkylene or alkenylene chain; are formed by conjugating a suitable polymer to a suitable biologically active molecule via nucleophilic groups in said molecule, preferably via a disulphide bridge.

Novel biologically active compounds of the general formula (I) in which one of X and X' represents a polymer, and the other represents a hydrogen atom; each Q independently represents a linking group; W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety; or, if X&#x2032; represents a polymer, X-Q-W- together may represent an electron withdrawing group; and in addition, if X represents a polymer, X&#x2032; and electron withdrawing group W together with the interjacent atoms may form a ring; each of Zand Zindependently represents a group derived from a biological molecule, each of which is linked to A and B via a nucleophilic moiety; or Zand Ztogether represent a single group derived from a biological molecule which is linked to A and B via two nucleophilic moieties; A is a Calkylene or alkenylene chain; and B is a bond or a Calkylene or alkenylene chain; are formed by conjugating a suitable polymer to a suitable biologically active molecule via nucleophilic groups in said molecule, preferably via a disulphide bridge. 

The invention relates to the inhibitory effects of dextrin sulphate on angiogenesis and in particular the treatment of diseases or disorders which would benefit from the administration of dextrin sulphate.

Treatment of angiogenesis dependent conditions with dextrin sulphate

A method of treating a patient having a highly vascular tumor includes administering a therapeutically effective amount of dextrin sulphate to the patient. The highly vascular tumor can be, for example, Kaposi's sarcoma. The treatment results in regression of the tumors and the improvement persists for a considerable time after completion of the treatment.

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Hertfordshire, United Kingdom

Sunil Shaunak