Therics, Inc.

Sunil Saini

Qing Wen Liu

Thomas George West

Jaedeok Yoo

Peter A Materna

Henry Leon Surprenant

Thomas J Bradbury

Donald C Monkhouse

Christopher M Gaylo

Chen-Chao Wang

Timothy J Pryor

Alfred Anthony Litwak

Kathleen D Chesmel

Jonathan McGlohorn

Mahesh Krishnan

Heather Ann Beam

Jennifer Patterson

Bone void filler pieces that are conducive to packing or nesting when a plurality of pieces are located in a cavity in random orientation. The bone void filler of the present invention includes a higher bulk packing density and a porosity of less than 80% to provide a better match native bone ingrowth rate. Further, the bone void filler includes a bi-modal pore distribution with a high frequency of smaller pores to enhance the density characteristic of the bone void filler pieces. A method of manufacturing the bone void filler pieces includes a precursor powder composition suitable to form a ceramic matrix; the preform is converted by chemical reaction to a final composition. The preform further includes the use of a porogen that decomposes to gaseous decomposition products upon heating.

Bone void filler and method of manufacture

An engineered regenerative biostructure (erb) for implantation into a human body as a bone substitute, which includes an internal microstructure, mesostructure and/or macrostructure to provide improved bone in-growth, and methods for making the erb. Under one aspect of the invention, the biostructure has resorbable and nonresorbable regions. Under another aspect of the invention, the biostructure is constructed of hydroxyapatite, tricalcium phosphate and/or demineralized bone. Under yet another aspect of the invention, the porous biostructure is partially or fully infused with a resorbable, nonresorbable or dissolvable material.

Method and apparatus for engineered regenerative biostructures such as hydroxyapatite substrates for bone healing applications

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Plainsboro, NJ, United States of America

Sunil Saini