Glenmark Pharmaceuticals S.a.

Sunil P Nirgude

Laxmikant Atmaram Gharat

Suresh Mahadev Kadam

Nagarajan Muthukaman

Sachin Baban Gavhane

Sandeep Bandu Khandagale

The present application relates to solid state forms of a triazolone compound which exhibit mPGES-1 enzyme inhibition activity, specifically N-(4-chloro-3-(5-oxo-1-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-1,2,4-triazol-3-yl)benzyl)pivalamide (Compound of formula II), and process for preparation thereof. 

Polymorphs of a mPGES-1 inhibiting triazolone compound

The present application relates to solid state forms of a triazolone compound which exhibit mPGES-1 enzyme inhibition activity, specifically N-(4-chloro-3-(5-oxo-1-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-1,2,4-triazol-3-yl)benzyl) pivalamide (Compound of formula II), and process for preparation thereof. 

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Maharashtra, India

Sunil P Nirgude