Mitobridge, Inc.

The Salk Institute for Biological Studies

Astellas Engineered Small Molecules US, Incorporated

Sunil Kumar Panigrahi

Arthur F Kluge

Bharat Lagu

Ronald Mark Evans

Michael A Patane

Michael Downes

Masanori Miura

Taisuke Takahashi

Ramesh Senaiar

Susanta Samajdar

Pranab Maiti

Provided herein are compounds and compositions useful in increasing PPAR&#x3b4; activity. The compounds and compositions provided herein are useful for the treatment of PPAR&#x3b4; related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).

PPAR agonists, compounds, pharmaceutical compositions, and methods of use thereof

The application relates to phenyl- or naphthylsulfonamide derivatives of the structural formula (I). The compounds are described as inhibitors of USP30 (ubiquitin specific peptidase 30) useful for the treatment of conditions involving mitochondrial defects including neurodegenerative diseases such as Alzheimer's and Parkinson's or a neoplastic disease such as leukemia. 

USP30 inhibitors

Provided herein are compounds I, II or III and compositions useful in increasing PPAR8 activity. The compounds and compositions provided herein are useful for the treatment of PPAR8 related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases). 

Provided herein are compounds of formula (I) useful for the treatment of PPAR-delta related diseases (e.g. mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic diseases). 

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Hyderabad Telangana, India

Sunil Kumar Panigrahi