New York University

Yale University

Sunil Kumar

Andrew D Hamilton

Andrew Miranker

Mazin Magzoub

Sarah Hassan

Pankaj H Rajput

Prabodh Panindre

The present invention provides novel compounds that are quinoline foldamers. Such foldamers stabilize and bind to islet amyloid polypeptide (IAPP). In certain embodiments, the quinoline foldamers of the invention are soluble and cross biological membranes without cellular assistance. The present invention further provides novel methods of preventing or treating diabetes in a subject in need thereof by administering to the subject an effective amount of at least one quinoline foldamer of the invention. The present invention further provides novel methods of preventing or treating a neurodegenerative disease caused by a misfolded and/or unstructured protein in a subject in need thereof by administering to the subject an effective amount of at least one quinoline foldamer of the invention.

Quinoline amides and methods of using same

An exemplary engine noise reduction system, can be provided, which can include a noise reduction fluid source, and a microjet(s) placed at an axial location downstream from a nozzle exit of an engine and configured to asymmetrically inject a noise reduction fluid from the noise reduction fluid source into a jet flow of the engine. The engine can be a jet engine. The microjet(s) can include four microjets, which can be about 90 degrees apart in a plane at the axial location. The four microjets can be asymmetric microjets. The microjet(s) can be configured to inject the noise reduction fluid in a direction that is normal with respect to the jet flow.

Directionally targeted jet noise reduction system and method

The present invention provides novel compounds that are quinoline foldamers. Such foldamers stabilize and bind to islet amyloid polypeptide (IAPP). In certain embodiments, the quinoline foldamers of the invention are soluble and cross biological membranes without cellular assistance. The present invention further provides novel method of preventing or treating diabetes in a subject in need thereof by administering to the subject an effective amount of at least one quinoline foldamer of the invention. The present invention further provides novel method of preventing or treating a neurodegenerative disease caused by a misfolded and/or unstructured protein in a subject in need thereof by administering to the subject an effective amount of at least one quinoline foldamer of the invention.

The invention relates to compounds and pharmaceutical compositions capable of treating amyloid diseases and other diseases characterized by oligomerization and/or fibrillation of amyloidogenic peptides such as islet amyloid polypeptide (IAPP).

Oligopyrroles as antagonists of islet amyloid polypeptide oligomerization

The invention relates to compounds and pharmaceutical compositions capable of treating amyloid diseases and other diseases characterized by oligomerization and/or fibrillation of amyloidogenic peptides such as amyloid beta peptide (Abeta or A&#x3b2;).

Alpha-helix mimetics as modulators of Abeta self-assembly

The use of microresonators with sharp corners (rectangular and square-shaped) can be limited by severe energy loss at the corners. The effect of incorporating fillet design at sharp corners (rounding of corners) of such single mode optical microresonators is described. The effect on quality factor, free spectral range ('FSR'), and energy loss for varying values of fillet radii are quantified and compared with standard circular microring resonator. It is shown that the selection of optimum fillet radius for sharp-cornered microresonators provide higher quality factor than that of the conventional circular resonators.

Closed loop microresonators having linear portions and filleted corners, systems including such microresonators, and methods of fabricating such microresonators

The invention relates to oligopyridylamide alpha-helix mimetic compounds and their use to inhibit p53 aggregation and restore its tumor suppressor function for treating diseases, e.g., cancers, associated with p53 mutations, e.g., R248W p53 mutation.

Growing community of inventors

New York, NY, United States of America

Sunil Kumar