Multivir Inc.

The University of Texas System

Intrexon Corporation

Precigen, Inc.

Introgen Therapeutics Inc.

Sunil Chada

Robert E Sobol

William E Fogler

Charles C Reed

Elizabeth A Grimm

Fayaz Khazi

Jeremiah F Roeth

Brandon Cuthbertson

Abner Mhashilkar

Rajagopal Ramesh

Dora Wiederhold

Kerstin B Menander

Raymond E Meyn

John B Mumm

Provided herein are methods and compositions for treating cancer in an individual comprising administering to the individual an effective amount of at least one CD 122/CD 132 agonist, at least one immune checkpoint inhibitor and a viral composition comprising one or more viruses engineered to overexpress a tumor suppressor gene and/or an adenoviral death protein. Also provided herein are methods and compositions for treating cancer in an individual comprising administering to the individual an effective amount of at least one oncolytic viral composition and at least one CD122/CD132 agonist and at least one immune checkpoint inhibitor. Also provided herein are methods of enhancing anti-tumor efficacy by administering the agents described above in combination with other cancer therapies. In highly aggressive forms of cancer, known to be generally resistant to immune therapies, these treatments unexpectedly resulted in complete tumor remissions and curative outcomes.

Methods and compositions comprising tumor suppressor gene therapy and CD122/CD132 agonists for the treatment of cancer

Growing community of inventors

Houston, TX, United States of America

Sunil Chada