Oscotec Inc.

Genosco

Sunhwa Chang

Se-Won Kim

Jong Sung Koh

Jaekyoo Lee

Hong Woo Kim

Jung-Keun Kim

Seon-Yle Ko

Jang-Sik Choi

Ho-Juhn Song

Hee Kyu Lee

Hyung-Gun Kim

Dong-Heon Baek

Youngsam Kim

Sun-Hee Lim

Jung-Ho Kim

Dong Sik Jung

Byung-Eui Lee

Heejong Woo

Youngnim Choi

Seong-Hee Ko

Jong-Yeo Kim

Hyung-Gun 5-108 Jinheung Apt Kim

Jung-Keun 114-302 Hyundai Apt Kim

Seong-Hee 101-802 Cheongsong Apt Ko

Heejong 306-1807 Hyangchonhyundai Apt Woo

Byung-Eui 102-106 Life Saeyeoul Apt Lee

Youngnim College Of Dentistry Choi

The present invention provides a new group of protein kinase inhibitors, pyrropyrimidine and pyrazolopyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof that are useful for treating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrropyrimidine and pyrazolopyrimidine derivatives.

Kinase inhibitors

The present invention provides a new group of protein kinase inhibitors, pyrido[4,3,-d]pyrimidin-5-one derivatives, and pharmaceutically acceptable salts thereof that are useful for intreating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrido[4,3,-d]pyrimidin-5-one derivatives.

The present invention relates to an extract of an herbal mixture ofand, and a method for treating arthritis using the extract as an effective ingredient. The extract of the herbal mixture of the present invention can effectively inhibits the release of inflammatory substances and the synthesis of cartilage destroying substance as well as the progress of arthritis.

Herbal mixture extract of notoginseng radix, rehmanniae radix preparata and acanthopanacis cortex and composition comprising the same for prevention and treatment of arthritis

The present invention relates to a composition comprising Notoginseng radix extract for preventing and treating arthritis as an effective ingredient. Notoginseng radix extract of the present invention inhibits release of tumor necrosis factor-alpha (TNF-&#x3b1;) and is the death of activated T-cells only, so that it can be effectively used for the production of a medicine for preventing and treating arthritis and health food as well.

Composition comprising Notoginseng radix extract for preventing and treating of arthritis as an effective ingredient

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Cheonan-si, South Korea

Sunhwa Chang