Seoul National University

Bionano Health Guard Research Center

Sungi Kim

Jwa Min Nam

Young Kwang Lee

Jinyoung Seo

Ha Hyung Park

Keunsuk Kim

A lipid nanotablet according to the present disclosure includes: a supported lipid bilayer having a plurality of nanoparticles integrated in nanoparticle units; an immobile nano-receptor including at least one first surface molecule from among the plurality of nanoparticles and coupled to the surface of the nano-receptor, and a mobile nano-floater including at least one second surface molecule from among the plurality of nanoparticles coupled to the surface of the nano-floater. Interaction between the nano-receptor and the nano-floater is controlled according to the result of a reaction to an input by the at least one first surface molecule and the at least one second surface molecule, and the lipid nanotablet provides a logic result on the basis of the interaction.

Lipid nanotablet

Disclosed herein are an artificial cell membrane including a supported lipid bilayer (SLB) including a substrate and mobility-decreased metal particles bonded onto the substrate; an analysis device or kit including the artificial cell membrane and examining the interactions between molecules, in which one molecule is bonded to the surface of a mobility-decreased metal particle bonded to the artificial cell membrane and the other molecule is bonded to the surface of a mobility-increased metal particle bonded to a lipid at a low valency; a method of examining the interactions between molecules using the analysis device; a kit for quantitative or qualitative analysis of a target material including the artificial cell membrane by plasmonic scattering measurements; and a multiple analysis kit capable of detecting a plurality of target materials using a plurality of metal particles having different plasmonic scattering wavelengths and/or having mobility on a supported lipid bilayer. According to the artificial cell membrane including a supported lipid bilayer containing metal particles attached thereto, the fluidity of the metal particles on the lipid can be controlled by adjusting the number of ligands bonded to the metal particles. Therefore, target molecules for analyzing the interactions therebetween on two types of metal particles having different fluidity are introduced onto the artificial cell membrane, thereby monitoring the movements of the metal particles through plasmonic scattering so as to analyze the interactions between the target molecules. In this case, multiple analysis of simultaneously detecting and quantifying a plurality of target materials using the artificial cell membrane of the present invention, plasmonic scattering wavelengths, and a plurality of particles having different fluidity can be performed.

Artificial cell membrane comprising supported lipid bilayer connected with probes having controllable mobility and method for analyzing interaction between molecules using the same

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Seoul, South Korea

Sungi Kim