Korea Research Institute of Bioscience and Biotechnology

Korea Research Institute of Chemical Technology

Daegu Gyeongbuk Institute of Science and Technology

Daegu-Gyeongbuk Medical Innovation Foundation

Sungchan Cho

Miri Choi

Sang Bum Kim

Hwan Geun Choi

So Young Kim

Kyeong Seok Lee

Jung Beom Son

Nam Doo Kim

Yi Kyung Ko

Seungyeon Lee

Seock Yong Kang

Joo Youn Lee

Sun-Hwa Lee

Jin-Hee Park

Eunhwa Ko

Yongseok Choi

Dayea Kim

Hyun Sun Lee

Sun Joo Lee

Hee Yoon Ryu

Joong-heui Cho

Kyu-Sun Lee

Ja Wook Koo

Hyang-Sook Hoe

Mun-Ock Kim

Jeong-Jun Park

Jee-Hee Seo

Hwayoung Jung

Kweon Yu

The present invention relates to a pyrrolo-pyridine derivative compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for the prevention or treatment of protein kinase-related diseases. A compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has excellent inhibitory activity against various protein kinases including DYRK1A, and therefore, the pharmaceutical composition containing the same as an active ingredient can be favorably used in the treatment or prevention of protein kinase-related diseases. Particularly, the pharmaceutical composition can be effectively used in the prevention, treatment, or alleviation of Alzheimer's disease, dementia, or Alzheimer's dementia.

Pyrrolo-pyridine derivative compound, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of protein kinase-related diseases

The present invention relates to a pharmaceutical composition the prevention or treatment of DYRK-related diseases containing a pyridine-based compound as an active ingredient, a pyridine-based compound of the present invention which is used as an active ingredient of the pharmaceutical composition inhibits the activity of DYRK1A with very high efficacy and selectivity, thereby can be used effectively in the prevention or treatment of DYRK-related diseases, such as Down syndrome, degenerative brain diseases, cancer, and metabolic diseases.

Pharmaceutical composition for preventing or treating DYRK-related diseases, containing pyridine-based compound as active ingredient

The present invention relates to an indole derivative, The indole derivative according to the present invention effectively inhibits the activity of diacylglycerol acyltransferase (DGAT) which induces metabolic diseases, such as obesity, diabetes, hyperlipidemia, or fatty liver and the like in lipid metabolism, thereby effectively regulating lipid metabolism and energy metabolism, and thus can be useful in pharmaceutical compositions for preventing or treating metabolic disease.

Indole derivative or pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition for preventing or treating metabolic diseases containing same as active ingredient

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Daejeon, South Korea

Sungchan Cho