Biobud Co., Ltd.

Yonsei University

Nc Bit Inc.

Sung Yu Hong

Kwang Hoe Chung

Young Dae Kim

Jae Hoon Hwang

Il Kwon

Ji Hoe Heo

Bum Joon Kim

Gyu Hwan Yon

Yang Soo Jang

Hyeon Kyu Lee

Chwang Siek Pak

Heui Cheol Yang

Eun Bok Choi

Ok Hwan Kim

Kyoung Jun Kim

Dong Ik Kim

Ji Hun Shin

Hyeon-kyu Lee

Hyun Ju Doh

Young Doug Sohn

Jae Hoon Lim

Jin Sub Choi

Soo Jung Kang

Sung Joong Kim

Young-Doug Sohn

The present invention relates to a saxatilin derivative having an increased half life and a use thereof. The saxatilin derivative of the present invention has thrombolytic ability similar to that of saxatilin, which is the mother protein, a remarkably increased protein half life, and efficiently dissolves, for long period of time, blood clots already formed in blood vessels of an animal model with a FeCl-induced carotid by using the same. Therefore, a composition containing, as an active ingredient, the saxatilin derivative of the present invention does not cause reocclusion after penetration and effectively opens to microvessels, and is thus very useful for treating angiostenosis or occlusive diseases (for example, cerebrovascular diseases, cardiovascular diseases, arteriosclerotic vascular diseases, coronary artery diseases, and peripheral vascular diseases).

Method for treating vascular stenosis or occlusive disease due to thrombi by administering a saxatilin-fc fusion protein

The present invention relates to: a composition for dissolving thrombi comprising a peptide comprising the Arg-Gly-Asp motif; a pharmaceutical composition for treating stenotic or occlusive vascular diseases which comprises the same; and a thrombus dissolving method and a method for treating stenotic or occlusive vascular diseases, comprising the step of administering the same. The compositions and methods of the present invention have the advantage that they effectively break down already formed thrombi by adopting the principle of targeting integrin within the thrombus such as platelet surface GPIIb-IIIa, which is not the same as the existing principle of plasminogen activation. Also, the compositions and methods of the present invention have a nerve-protecting function as they effectively open as far as the microvasculature, without the occurrence of restenosis after penetration.

Composition for dissolving thrombi, and a pharmaceutical composition for treating stenotic or occlusive vascular diseases which comprises the same

Provided is a method for preparing an epoxy substrate having a nanopattern, including: (a) forming a titanium oxide film by anodizing a titanium substrate; (b) obtaining a titanium substrate having a concave shape formed on the surface by removing the titanium oxide film from the titanium substrate on which the titanium oxide film has been formed; (c) coating an epoxy resin onto the titanium substrate on which the concave shape has been formed; and (d) obtaining an epoxy substrate having a nanopattern of convex surfaces by removing the titanium substrate.

Production method for a nanopatterned epoxy substrate

The present invention relates to a batroxobin-encoding nucleotide sequence and/or a mutated &#x3b1;-factor secretion signal sequence, and a vector and a transformant using the same. The batroxobin-encoding nucleotide sequence of this invention exhibits an excellent expression efficiency in yeast, particularand the recombinant batroxobin is obtained at 4-13 fold higher yield than natural-occurring batroxobin-encoding sequences. The protein expression system which uses the batroxobin-encoding nucleotide sequence as well as mutated &#x3b1;-factor secretion signal peptide sequence of this invention obtains the recombinant batroxobin at about 20-fold higher yield than natural-occurring batroxobin-encoding sequences. In addition, the recombinant batroxobin prepared using the sequence of this invention has a significantly plausible activity and stability compared with natural-occurring batroxobin.

Mutated nucleotide sequences of batroxobin, mutated &#x3b1; factor secretion signal sequence and processes for preparing batroxobin using the same

The present invention relates to a method for treating or reducing the development of a hyperproliferative disorder, which comprises administering to a subject a composition, 

Compositions for treating hyperproliferative vascular disorders and cancers

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Seoul, South Korea

Sung Yu Hong