Korea Research Institute of Chemical Technology

Yonsei University

Kyung Nong Corporation

Sung Youn Chang

Jung Nyoung Heo

Seong Hwan Kim

Ki Young Kim

Sung Soo Kim

Hyuk Soo Lee

Bum Tae Kim

Hwan Jung Lim

Hyuk Jin Lee

Sang Youn Park

Eun Sook Hwang

Sang Joon Shin

Hyuk Jae Lee

Sung-Eun Yoo

Kyu Yang Yi

Jee Hee Suh

Nak Jeong Kim

Myung-Ae Bae

Jeong-Ho Hong

Namsook Kang

Nack Jeong Kim

Sung Eun Yoo

Myung Ae Bae

Nam Sook Kang

Zang Hee Lee

Hyun-Mo Ryoo

Joo Kyung Kim

Jong-Kwan Kim

Jong -Kwan Kim

The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disclosure also provides a medical use of the compound, its salt or the composition comprising the compound or its pharmaceutically acceptable salt for treating or preventing cancer. The present disclosure also provides a method of treatment or prevention of cancer comprising administering the compound, its salt or the composition comprising the compound or its salt to a subject in need of such treatment or prevention.

Compounds for inhibiting TNIK and medical uses thereof

Hetero ring-fused phenyl compounds for inhibiting TNIK and medical uses thereof

A pharmaceutical composition comprising a phenyltetrazole derivative of formula (I) or a pharmaceutical acceptable salt thereof is effective in preventing or treating osteoporosis, obesity, diabetes, or hyperlipidemia, by regulating protein TAZ.  wherein, A is ethyl or n-butyl; Ris methyl, &#x2014;CHOH, &#x2014;COCH, &#x2014;CHF, &#x2014;CH(OCH), &#x2014;CHOC(&#x2550;O)CH, styryl or &#x2014;CHOCHSCH; Ris H, Br, &#x2014;COCH, phenyl, pyridin-2-yl, pyridin-3-yl, or styryl; Ris H or methyl; X is CH or N; and P is H or &#x2014;CH(CH)OCHCH.

Pharmaceutical composition for preventing or treating osteoporosis or obesity comprising phenyltetrazole derivative

The invention relates to diaminoaryl derivatives substituted by carbamate, salts thereof and a pesticidal composition containing the same, which exhibit superior pest control effects against various insect pests of insect species, in particular against moths such as the diamondback moth or

Diaminoaryl derivatives substituted by carbamate and pesticidal composition containing same

An indenone derivative of formula (1) is effective in enhancing the activity of osteoblastic cells and inhibiting bone resorption by osteoclastic cells, and a pharmaceutical composition comprising the indenone derivative or a pharmaceutically acceptable salt thereof is useful for preventing or treating bone diseases such as osteoporosis.

Indenone derivative and pharmaceutical composition comprising same

The present invention relates to an amide compound or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition comprising the same. The inventive amide compound facilitates bone formation and inhibits bone loss, and is therefore useful for preventing and treating bone disorders such as osteoporosis, osteodystrophy, bone fracture, periodontal disease, Paget's disease, bone metastasis, and rheumatoid arthritis.

Isoindolinone derivatives, preparation method thereof and a pharmaceutical composition comprising same

A phamaceutical composition comprising a phenyltetrazole derivative of formula (I) or a pharmaceutical acceptable salt thereof is effective in preventing or treating osteoporosis, obesity, diabetes, or hyperlipidemia, by regulating protein TAZ.  

Growing community of inventors

Daejeon, South Korea

Sung Youn Chang