Chong Kun Dang Pharmaceutical Corporation

Sung-Sook Lee

Young-Hoon Kim

Seung-Kee Moon

Soon-Kil Ahn

Nam-Song Choi

Jae-Kwang Lee

Ho-Jin Choi

Soo-Jin Kim

Jae-Hoon Choi

Hyun-Mo Yang

Young-Mi Kim

Sun-Ju Kong

Young-Min Kwon

Jae-Su Shin

Hyun-Jung Yu

In-Taek Lim

Su-Yeal Bae

Kyung-Joo Lee

Dal-Hyun Kim

Byeong-Hoon Han

Gyu-Tae Park

Hee-Ryong Kang

Disclosed are a novel thiazole-containing benzophenone derivative represented by formula 1, and an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof and a solvate thereof, a pharmaceutical composition comprising the derivative, a use of the derivative as therapeutic agent and a method for preparing the derivative. The benzophenone thiazole derivatives inhibit formation of microtubules and eliminate actively proliferating cells of malignant tumors to control general cell proliferation. In formula 1, R, Rand Rare defined as above.

Benzophenone thiazole derivatives useful for inhibiting formation of microtubule and method for producing the same

Disclosed herein are novel benzophenone derivatives represented by formula I, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof, a pharmacological composition containing the same, and a use of the composition as therapeutic drugs. The benzophenone derivatives have an inhibition activity of microtubule formation and can be used to treat a normal proliferative state of a malignant tumor by killing the actively proliferating cells.

Benzophenone derivatives useful for inhibiting formation of microtubule

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Cheonan-si, South Korea

Sung-Sook Lee