University of Miami

Other

Westwood Pharmaceuticals, Inc.

Sung Lan Hsia

Niven Rajin Narain

Indushekhar Persaud

Karrune Veeraprasert Woan

Kathryn J Russell

Jie Li

Marty Sawaya

Walter Voigt

Kathryn Zeoli

Jin L He

Paul L Warner, Jr

Jeffrey S Pinto

Kathryn J Rusell

CoQlO has a stimulatory effect on fibroblasts and keratinocytes, increases ATP production, decreases pain. The formulations are useful for promoting acute wound healing, fatigue and treatment of acute and chronic pain.

Topical co-enzyme Q10 formulations and treatment of pain, fatigue and wounds

Topical formulations of CoQ10 reduce the rate of tumor growth in an animcal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin cancer cells but not normal cells. Moreover, treatment of tumor-bearing animals with a topical formulation of CoQ10 was shown to dramatically reduce the rate of tumor growth in the animals.

Topical co-enzyme Q10 formulations and methods of use

Topical formulations of CoQ10 reduce the rate of tumor growth in an animal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin cancer cells but not normal cells. Moreover, treatment of tumor-bearing animals with a topical formulation of CoQ10 was shown to dramatically reduce the rate of tumor growth in the animals.

Co-enzyme Q10 formulations and methods of use

The present invention relates to a method of modifying serum cholesterol levels in a mammal by topically administering to the skin of the mammal an effective amount of at least one phospholipid. Atherosclerosis, and related complications, can be treated, or prevented, using the present method.

Treatment for hypercholesterolemia

Disorders of the skin resulting from over androgenicity, such as acne vulgaris, may be treated by applying, to affected areas of the skin, a composition containing a therapeutically effective amount of pregnenolone.

Treatment of skin over androgenicity using compositions containing

Treats living skin in which sebum secretion is excessive with certain triglycerides to reduce the level of sebum secretion.

Method for treating living skin exhibiting excessive sebum secretion

The ability of serum to bind cholesterol in soluble lipoprotein complexes is believed to retard the deposition of cholesterol in atherosclerotic plaques. This ability is measured by 'serum cholesterol binding reserve' (SCBR), defined as the amount of exogenous cholesterol which a serum specimen is capable of solubilizing in addition to its cholesterol content. A method for determining SCBR has been developed. An excess amount of cholesterol is added to a sample of blood serum and incubated. The amount of cholesterol solubilized by the serum is then measured. Test results in case-control studies of premature myocardial infarction have demonstrated the usefulness of SCBR in assessing the risk of coronary heart disease.

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Miami, FL, United States of America

Sung Lan Hsia