Dongkook Pharmaceutical Co., Ltd.

Sung Ki Seo

Yong Hyun Kim

Jin Kyu Park

Hee Young Beom

Hyeung Geun Park

Sang Sup Jew

Jeong Hoon Kim

Han Won Lee

Hee Doo Kim

Hee Man Kim

Won Hun Ham

Doo Yeon Lim

Young Choong Kim

Young Hoon Jung

Chi Hyoung Yoo

Tae Gyu Nam

Ducky Han

Pil Jong Shim

Ju Eun Jung

Kyung Seok Choi

Kee Young Lee

Hong Pyo Kim

Chang Young Oh

Eung Seok Lee

So Ra Kim

Hee Sung Choi

Mi Kyeong Lee

Jae Ho Park

Ki Young Lee

Min Sung Park

Disclosed is the use of 2-oxoasiatic acid in the treatment of dementia or cognitive disorders.

Medicines for treating dementia or cognitive disorder, which comprises asiatic acid derivatives

The present invention relates to stereoselective synthetic method of oxazoline derivative. More particularly, it relates to a synthetic method of oxazoline derivative having the structure of formula I. ##STR1## wherein R represents phenyl, benzyl, methyl, ethyl, isopropyl, isobutyl, cyclohexyl or cyclohexylmethyl.

Stereoselective synthesis of oxazoline derivative

The present invention relates to a process for the preparation of an oxazoline compound which is easily chemically converted to a beta-amino-alpha-hydroxy acid or a gamma-amino-beta-hydroxy acid. The method comprises producing a compound of the following formula (4) using .alpha.-amino acid. The produced compound (4) is subjected to an intramolecular cyclization to produce an oxazoline compound of the following formula (3). The oxazoline compound (3) is oxidized at a vinyl group with RuCl.sub.3 or NaIO.sub.4 to produce an oxazoline compound of the following formula (1) which is easily chemically converted to a beta-amino-alpha-hydroxy acid. Alternatively, the oxazoline compound (3) may also be treated with 9-borabiclo[3.3.1]nonane such that a hydroxy group is introduced into the end of the vinyl group of the oxazoline compound(3). The introduced end hydroxy group is oxidized with RuCl.sub.3 or NaIO.sub.4 to produce an oxazoline compound of the following formula (2) which is easily chemically converted to a gamma-amino-hydroxy acid.

Process for the preparation of oxazoline compound

Asiatic acid derivatives having modified A-ring

Growing community of inventors

Pusan, South Korea

Sung Ki Seo