Postech Academy-industry Foundation

Korea Institute of Science and Technology

Seoul National University

Posco

Postech Foundation

Korea Food & Drug Administration

Lg Chemicals Co. Ltd.

Sung Key Jang

Jong Hun Im

Hee Sun Kim

Jung Hwan Lee

Jong In Kim

Sung Ho Ryu

Young Chan Chae

Ki Seok Kim

Youndong Kim

Hyungu Kang

Hye Jung Lee

Gyo Chang Keum

Byeong Moon Kim

Mi-Jin Kwon

Il Hak Bae

Soon Hag Kim

Eun Jung Jang

Sun Hak Lee

Thomas P Russell

Ae Nim Pae

Soon Bang Kang

Jin Hyeong Park

Seung Yun Yang

Jin Kon Kim

Eunice Eun-Kyeong Kim

Eun Ju Oh

Juhyeon Lee

Won Jun Kang

Jiyoun Lee

Eunice Eun Kyeong Kim

Young Su You

Seung Gi Lee

Hua Li

Jin Kyu Choi

Min Jeong Choi

Heejo Moon

Byeong Wook Kim

Jaegon Mun

Jin Sook Kwak

Na-Oh Yunn

Bumsuk Hahm

Hwang Yong Kim

Incheol Ryu

Min Soo Park

Sun Ju Keum

Seungmin Han

Suyeon Yeom

Ara Koh

SeungGi Lee

Sehoon Park

Il Ung Oh

Youngdong Kim

The present invention relates to a fluorene derivative or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition comprising the same as an effective ingredient for preventing or treating HCV-related disease. A fluorene derivative according to the present invention is identified to exhibit an antiviral performance against not only HCV, but also highly against HCV mutants, particularly double mutants and thus can be used in a pharmaceutical composition for prevention or treatment of HCV-caused liver disease, such as acute hepatitis C, chronic hepatitis C, liver cirrhosis, hepatocellular cancer, etc., particularly, liver disease caused by mutants of HCV. The derivative can be useful in a pharmaceutical composition for prevention or treatment of HCV-related liver disease by which the problem of resistant mutation against conventional therapeutic agents is solved.

Fluorene derivative or pharmaceutically acceptable salt thereof, preparation method therefor, and pharmaceutical composition comprising same as effective ingredient for preventing or treating HCV-related disease

The present disclosure relates to a DNA aptamer which specifically binds to an insulin receptor, and a composition for treating diabetes and a composition for diagnosing diabetes which contain the same as an active ingredient, and the aptamer is characterized by being able to treat and diagnose diabetes more effectively than side effects caused by insulin such as increased incidence of cancer and atherosclerosis by having a different binding mechanism from existing insulin.

Aptamer against insulin receptor and pharmaceutical compostion containing the same

The present invention relates to a carbazole compound having anti-virus activity, and more particularly, to a novel compound selected from the group of consisting of a carbazole compound which shows excellent anti-proliferative efficacy against hepatitis C virus (HCV), a pharmaceutically acceptable salt thereof, a hydrate thereof, and an isomer thereof; an anti-virus pharmaceutical composition including the novel compound as an active ingredient; a pharmaceutical composition for preventing or treating liver diseases caused by hepatitis C virus; and a method of preparing the novel compound.

Carbazole compound having anti-virus activity

The disclosed compounds have antiviral activity against C-type virus, an optical isomer thereof, a pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating liver disease caused by hepatitis C virus. The benzidine derivative according to the present invention has excellent antiviral activity against hepatitis C virus and exhibits excellent medicinal activity in the living body, and thus the pharmaceutical composition containing the same as an active ingredient can be useful as a pharmaceutical composition for preventing or treating liver disease, such as acute hepatitis C, chronic hepatitis C, cirrhosis, or hepatocellular carcinoma, caused by C-type virus.

Benzidine derivative, method for preparing same, and pharmaceutical composition containing benzidine derivative for treating liver disease caused by hepatitis C virus

The present invention relates to oxazolidinone compounds represented by Chemical Formula 1, pharmaceutically acceptable salts thereof or hydrates, a method of preparing the same, and a pharmaceutical composition for preventing or treating Hepatitis C infection: 

Oxazolidinone derivatives and composition for preventing or treating hepatitis C containing the same

Disclosed are a DNA aptamer specifically binding to the Her2 (ERBB2) receptor involved in the onset of breast cancer, a composition for the suppression of cancer metastasis comprising the same as an active ingredient, and a composition for the diagnosis of cancer comprising the same as an active ingredient. Due to its binding mechanism being different from that of the conventional antibody, the aptamer can be effectively used for suppressing cancer metastasis and diagnosing cancer.

Aptamer which selectively binds to ERBB2 receptor and uses thereof

Improved G-rich oligonucleotide (GRO) aptamers specific to nucleolin, a method of preparing the aptamers, and a use of the aptamers for diagnosing and/or treating a nucleolin-associated disease, are provided.

Method of diagnosing cancer using a nucleolin specific aptamer

Method of treating hyperproliferation of cells using a nucleolin specific aptamer

Provided are a nanoporous membrane and a method of fabricating the same. The nanoporous membrane includes a support, and a separation layer including a plurality of nano-sized pores at a density of 10/cmor greater and a matrix. The nanoporous membrane has a high flux and a high selectivity.

Nanoporous membrane and method of fabricating the same

The present invention provides a hybrid virus comprising poliovirus and the hepatitis C virus protease NS3 and a target site for NS3. The hybrid virus is useful for screening for drugs against hepatitis C virus.

Hepatitis C surrogate virus for testing the activity of hepatitis C virus protease, a recombinant gene and a use thereof

Growing community of inventors

Pohang-si, South Korea

Sung Key Jang