Korea Research Institute of Bioscience and Biotechnology

Sung-Keun Rhee

Jae Su Song

Moon-Hee Sung

Kwang Soo Kim

Seung-Pyo Hong

Seung-Goo Lee

Chul-Joong Kim

Su-Mi Kim

Jin-Woo Bae

Che Ok Jeon

Joong-Jae Kim

Dae-Joong Kang

The present invention relates to a novel obligately symbiotic thermophileSC-1 (Accession NO: KCTC 0685BP), and a thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase produced bySC-1. The present invention also relates to a pure culture method ofSC-1, a method of growth measurement forSC-1 and its relative symbiotic bacteria showing low-growth yield using nitrate respiration, and a screening method of relative symbiotic strains ofSC-1 from the environment using a specific antibody to it. Therefore, the thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase produced bySC-1 in this invention can provide more stable catalysts in enzymatic biotransformation processes which enzymatically produce valuable medico-amino acids 3,4-dehydroxy-L-phenylalanine (L-DOPA) and L-tryptophan.

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The present invention relates to a novel obligately symbiotic thermophileSC-1(Accession NO: KCTC 0685BP), and a thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase produced bySC-1. The present invention also relates to a pure culture method ofSC-1, a method of growth measurement forSC-1 and its relative symbiotic bacteria showing low-growth yield using nitrate respiration, and a screening method of relative symbiotic strains ofSC-1 from the environment using a specific antibody to it. Therefore, the thermostable L-tyrosine phenol-lyase and L-tryptophan indole-lyase produced bySC-1 in this invention can provide more stable catalysts in enzymatic biotransformation processes which enzymatically produce valuable medico-amino acids 3,4-dehydroxy-L-phenylalanine (L-DOPA) and L-tryptophan.

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Daejeon-si, South Korea

Sung-Keun Rhee