Korea United Pharm, Inc.

Bcworld Pharm. Co., Ltd.

Yonsei University

Alza Corporation

Huons Co., Ltd.

Sung Joo Hwang

Jae Hyun Kim

Jeong Soo Kim

Liang-Chang Dong

Kwang Ho Cha

Min Soo Kim

Bo Kyung Sun

Junsung Park

Won Kyung Cho

Wonkyung Cho

Suk Jun Seo

Donggeon Gu

Jun Sung Park

Chanhyuk Park

Kwang-Ho Cha

Hee Jun Park

Wei-guo Dai

Dong Ho Lee

Han Kang

Tae-Hong Choi

Disclosed is a method for preparing a liposome formulation. In the disclosed method, a lipid fraction is dissolved in an organic solvent. The solution including a bioactive component and the lipid fraction, together with a carrier, is put in a reaction vessel, and a supercritical fluid is introduced thereto, so as to prepare particles coated with the bioactive component-lipid. The supercritical fluid is discharged by compression to obtain proliposome particles, and then the proliposome particles are hydrated by an aqueous solution including water so as to form a liposome solution. Preferably, the formulation may include one or more bioactive components. As required, the liposome formulation may be further processed by methods such as particle size reduction, removal of organic solvent, and freeze-drying. The preparation method can be easily carried out at a laboratory scale. Furthermore, the same method can be employed in liposome formulation preparation in mass production, or at a commercial scale.

Method and apparatus for preparing novel liposome

The present invention relates to a novel technology for forming fine particles with a size of 0.0&#x2dc;23 microns from a solid that can be dissolved in a liquid solvent and is not decomposed by heat. The particle preparation technology according to the present invention may be applicable to the fields of food, cosmetics, biopolymer, polymer compositions, and pharmaceuticals.

Manufacturing method and apparatus of ultrafine particles having uniform particle size distribution

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Seoul, South Korea

Sung Joo Hwang