Nymirum, Inc.

Sung-Hun Bae

Hashim M Al-Hashimi

Andrew Corbet Stelzer

Michael Edward Pape

Aaron Terrence Frank

Mitchell Alan McBrairty

Joshua Paul Fairbank

Described herein is technology for determining the 2-D or 3-D atomic resolution structure of a polynucleotide bound to and/or interacting with another molecule, for example a small molecule. In some aspects of the technology, NMR and isotopic labeling strategies are used. The technology described herein is useful for a plurality of applications including but not limited to drug discovery and chemical biology probe discovery.

Small molecule binding pockets in nucleic acids

The present invention provides a method for determining the 3-dimensional or 3-D atomic resolution structure of a biomolecule using chemical shift data obtained from the biomolecule having one or more selectively isotopically labeled biomolecule monomers and interrogation of same using an NMR device. Methods also comprise use of a low-field NMR device and structure determination method to determine the 2-D and 3-D structure of the biomolecule, for example, a polynucleotide.

Device and methods for analysis of biomolecule structure, dynamics and activity

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Ann Arbor, MI, United States of America

Sung-Hun Bae