Korea Ocean Research and Development Institute

Sung Gu Lee

Joung Han Yim

Il Chan Kim

Se Jong Han

Tai Kyoung Kim

Ha Ju Park

Hyoung Seok Lee

Pil-Sung Kang

Doc Kyu Kim

Heeyong Park

Sung Jin Kim

Hyun Cheol Oh

Mi Ra Park

Dockyu Kim

Hong Kum Lee

Hari Datta Bhattarai

Yu-Kyeong Park

Paudel Babita

Yoo Kyung Lee

Hye Yeon Koh

Soon Gyu Hong

Seung Jin Kim

Babita Paudel-Bhattarai

Suhkneung Pyo

The present invention relates to the novel use (anti-inflammatory activity) of Ramalin isolated from the Antarctic lichen, and more specifically to a pharmaceutical composition containing Ramalin as an active ingredient. Ramalin of the invention is a compound derived from natural material, has no toxicity or side effects, and inhibits the expression of inducible nitric oxide synthase (iNOS) in the transcription stage to significantly inhibit the production of nitric oxide (NO) that is a key mediator of inflammatory responses. In addition, it inhibits the activation of the inflammatory mediator NF-&#x3ba;B, inhibits p38 MAPK, ERK1/2 and JNK signaling pathways, and inhibits the expression of the LPS receptor TLR4, suggesting that Ramalin has an excellent anti-inflammatory effect. Thus, the composition containing Ramalin can be effectively used to fundamentally treat or prevent inflammatory diseases or immune diseases and to relieve or alleviate the symptoms of the diseases.

Pharmaceutical composition for the prevention or treatment of inflammatory diseases or immune diseases containing ramalin

The present invention relates to a method for synthesizing ramalin, and more particularly to a method for synthesizing ramalin, which comprises allowing 2-hydrazinylphenol to react with L-glutamic acid having a protected carboxyl group at C-1 and a protected amino group at C-2, and a method for preventing decomposition of the ramalin. According to the present invention, ramalin having excellent antioxidant and anti-inflammatory activities can be synthesized in high yield, and thus can be produced in large amounts. In addition, ramalin can be stably maintained for a long period of time, and thus can be easily used for industrial purposes.

Method for preparing ramalin

The present invention relates to a novel compound having excellent antioxidant activity, isolated from, and more particularly to a novel compound, RAMALIN&#x2122;, having excellent antioxidant activity, isolated from the Antarctic lichen, a method for preparing the RAMALIN&#x2122;, and a pharmaceutical composition, a functional food and a functional cosmetic composition, which contain the RAMALIN&#x2122; as an active ingredient. The RAMALIN&#x2122; according to the invention has significantly excellent antioxidant effects compared to commercially available antioxidants, and thus can be widely used in agents for treating oxidation-related diseases, anti-aging functional foods, functional cosmetic products for skin whitening and wrinkle reduction, etc.

Compound ramalin and use thereof

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Incheon, South Korea

Sung Gu Lee