Korea Research Institute of Chemical Technology

Dongbu Hannong Chemical Co., Ltd.

Daewoo Electronics Co., Ltd.

The Industry & Academic Cooperation in Chungnam National University (iac)

Catholic University Industry Academic Cooperation Foundation

Yuyu, Inc.

Sung-Eun Yoo

Kyu Yang Yi

Jee Hee Suh

Seon-Ju Kim

Byung Ho Lee

Byung-Ho Lee

Kyu-Yang Yi

Nak-Jeong Kim

Jee-Hee Suh

Nak Jeong Kim

Ho-Won Seo

Hwa-Sup Shin

Young-Dae Gong

Hong Seok Lim

Sun Kyung Lee

Ho Won Seo

Sang-Hee Lee

Nak C Jeong

Hye-Ryung Kim

Wha-Sup Shin

Yi-Sook Jung

Young-Ah Shin

Sun-Ok Kim

Kyu S Jung

Sung-Hou Lee

Ok-Ja Cha

Jung Nyoung Heo

Choun-Ki Joo

Jong Yeon Hwang

Sung Youn Chang

Eunhee Kim

Eun Sook Hwang

Sun Kyung Hwang

Myung-Ae Bae

Hyae-Gyeong Cheon

Jeong-Ho Hong

Jin-Soo Seo

Hye-Suk Lee

Namsook Kang

Hwa Sup Shin

Dongsoo Jang

Young-Hoon Kim

Jin-Woo Kim

Chong Ock Lee

Jin-Ha Park

Jun-Sub Choi

Geun-Hyeog Lee

Moon-Kook Jeon

Nam Sook Kang

Hye-Sung Lee

Tae-Sung Koo

Soon-Hee Hwang

Jeehee Suh

Yun-Seok Cho

Young Sook Park

Yong-Sam Jung

In Sun Cho

Nakjeong Kim

Tae-Kyu In

Yun-Suk Lee

Haeyoung Suh

Dong-Ha Lee

Nack-Jeong Kim

In-Young Choi

Sun-Kyung Lee

Miae Namgoong

Hyun-Ju Bae

Cho Young Sik

Choi Hyung Sub

Jeon Hyun Suk

Song Jin Sook

Kim Chi Hyun

Young-Sik Cho

Jong-Yeon Hwang

Ji-Yeon Park

Sang-Un Choi

Jae-Sik Yang

Dongha Lee

Min-Young Park

Insun Cho

SunKyung Lee

Miae Namgung

Yong Oh Lee

Sunkyung Lee

Kyung-Hee Lee

Hyunsuk Lee

Kyung-Hee 204-1005 Pureunmaeul Byucksan Apt Lee

The present invention relates to a novel indene derivative, a preparation method for the same, and a pharmaceutical composition for treating retinal disease comprising the same as an active ingredient. The novel indene derivative of the present invention, the optional isomer of the same, or the pharmaceutically acceptable salts of the same have excellent inhibitory efficiency of receptor-interacting serine-threonine-protein kinase 1 (RIPK1). Therefore, the composition containing the same as an active ingredient can be effectively used as a pharmaceutical composition for treating retinal disease.

Fused heterocyclic ring compounds and method of treating retinal disease using same

The present invention provides a pharmaceutical composition for preventing or treating macular degeneration, which comprises benzopyran derivatives substituted with secondary amines including imidazole or pharmaceutically acceptable salts thereof as an active ingredient. The pharmaceutical composition of the present invention may be used in the form of eye drops.

Pharmaceutical composition for preventing or treating macular degeneration

A pharmaceutical composition comprising a phenyltetrazole derivative of formula (I) or a pharmaceutical acceptable salt thereof is effective in preventing or treating osteoporosis, obesity, diabetes, or hyperlipidemia, by regulating protein TAZ.  wherein, A is ethyl or n-butyl; Ris methyl, &#x2014;CHOH, &#x2014;COCH, &#x2014;CHF, &#x2014;CH(OCH), &#x2014;CHOC(&#x2550;O)CH, styryl or &#x2014;CHOCHSCH; Ris H, Br, &#x2014;COCH, phenyl, pyridin-2-yl, pyridin-3-yl, or styryl; Ris H or methyl; X is CH or N; and P is H or &#x2014;CH(CH)OCHCH.

Pharmaceutical composition for preventing or treating osteoporosis or obesity comprising phenyltetrazole derivative

A phamaceutical composition comprising a phenyltetrazole derivative of formula (I) or a pharmaceutical acceptable salt thereof is effective in preventing or treating osteoporosis, obesity, diabetes, or hyperlipidemia, by regulating protein TAZ.  

Provided are aminopyrazole derivatives, a process for the preparation thereof, and a composition for preventing or treating an ischemic disease containing the same. Since the aminopyrazole derivatives of the present invention can reduce an ischemic cell death significantly, they can be effectively used for the prevention and treatment of ischemic diseases mediated by ischemic cell death, or protection of organs.

Aminopyrazole derivatives, process for the preparation thereof, and composition for preventing or treating ischemic diseases containing the same

The present invention relates to benzopyran derivatives substituted with secondary amines including tetrazole, method for preparing thereof and pharmaceutical compositions containing them. The compounds of the present invention can be used for protecting neuronal cells and brain damage; antioxidation; inhibiting NO generation; protecting heart; suppressing angiogenesis; protecting preserving organs such as kidney, heart and tissue, and protecting organs in major cardiovascular surgery.

Benzopyran derivatives substituted with secondary amines including tetrazole, method for the preparation thereof and pharmaceutical compositions containing them

The present invention relates to a noble 6-alkylamino-2-methyl-2'-(N-methyl substituted sulfonamido)methyl-2H-1-benzopyran derivative, a method for preparing the same with high efficiency using a parallel synthetic method, one of combinatorial chemical synthetic techniques, and a use of the novel compound showing a high inhibitory effect to 5-lipoxygenase (5-LO) activity for preventing and treating leukotriene (LTA4, B4, C4, D4) activation-related diseases such as inflammatory diseases, rheumatoid arthritis, colitis, asthma and psoriasis.

6-Alkylamino-2-methyl-2'-(N-methyl substituted sulfonamido)methyl-2H-1-benzopyran derivative as anti-inflammatory inhibitor

When a multi-step process reaction is carried out in a solution, it generally requires several treatments and purification procedures to go through with after the reaction, however, the inventive method for preparing 2,2'-disubstituted-3,4-dihydro-7,8-disubstituted-6-amino benzopyran derivative using a solid-phased synthetic method simplifies the treatment and purification procedures after the reaction, which makes possible to efficiently construct numerous drug-like libraries. In particular, since the inventive method of the present invention comprises the steps of introducing a carbonate linker of formula 2 into Wang resin used as a common solid support (Step 1); synthesizing various benzopyran in a carbamate form of formula 3 as a key intermediate by reacting various amino benzopyran derivatives with the carbamate resin of formula 2 (Step 2); synthesizing 2,2&#x2032;-disubstituted-3,4-2H-6-substituted benzopyran resin of formula 4 (Step 3); and synthesizing 2,2&#x2032;-disubstituted-3,4-2H-6-alkylamino benzopyran derivative of formula 1 using a dichloromethane solution containing TFA or an organic solvent containing an organic acid, the inventive method is capable of efficiently synthesizing various 2,2&#x2032;-disubstituted-3,4-2H-6-alkylamino benzopyran derivatives. Consequently, the present invention has developed a new technique for constructing 2,2&#x2032;-disubstituted-3,4-2H-6-alkylamino benzopyran library using a solid-phase parallel synthetic method and makes increased the applicability of combinatorial chemical synthetic method. Further, 2,2&#x2032;-disubstituted-3,4-2H-6-alkylamino benzopyran derivative prepared by the inventive method has a high inhibitory effect to 5-lipoxygenase (5-LO) activity, and therefore, can be effectively used for developing a new propylactic or therapeutic drug for leukotriene activation-related diseases such as chronic inflammation, rheumatic arthritis, colitis, asthma and psoriasis.

6-alkylamino-2,2'-disubstituted-7,8-disubstituted-2H-1-benzopyran derivatives as 5-lipoxygenase inhibitor

The present invention relates to benzopyran derivatives substituted with secondary amines including imidazole, their preparation, and pharmaceutical compositions containing them. The present invention is pharmacologically useful for the treatment of cancer, rheumatoid arthritis, and diabetic retinopathies through anti-angiogenic properties, and also pharmacologically useful in the protection of heart and neuronal cells against ischemia-reperfusion injury or preserving organs.

Benzopyran derivatives substituted with secondary amines including imidazole, their preparation and pharmaceutical compositions containing them

The present invention provides (i) 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivatives; (ii) a process for synthesizing benzopyran derivatives with high efficiency by parallel synthesis on a solid-phase as one of combinatorial chemical synthesis technologies; and (iii) a use of the benzopyran derivatives for preventing and treating diseases or disorders induced by promotion of lipid peroxidation or accumulation of oxidized products.

6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivatives and their construction by parallel synthesis on solid-phase

Benzopyranyl heterocycle derivatives, process for preparation thereof, and pharmaceutical compositions containing them

The present invention relates to novel benzopyranyl guanidine derivatives of the formula 1, process for preparation therof and pharmaceutical use of the benzopyranyl guanidine derivatives. The benzopyranyl guanidine derivatives of the present invention can be used for protecting heart, neuronal cell or brain damage, preserving organs, and also the benzopyranyl guanidine derivatives are pharmacologically useful for inhibiting NO generation, and for suppressing lipid peroxidation, angiogenesis or restenosis.

Benzopyranyl guanidine derivatives, process for preparation thereof, and pharmaceutical compositions containing them

Pyridyl imidazole derivatives and processes for the preparation thereof

Imidazole derivatives and processes for the preparation thereof

Growing community of inventors

Gongju-si, South Korea

Sung-Eun Yoo