Korea Research Institute of Chemical Technology

Korea Research Institute of Bioscience and Biotechnology

Cj Corporation

Jeil Pharm. Co., Ltd.

Sung-Don Yang

Sung Soo Kim

Sang Dal Rhee

Won Hoon Jung

Hyae Gyeong Cheon

Jeong-Hyung Lee

Sung-eun Yoo

Seung Jun Kim

Jin Hee Ahn

Seung Kyu Kang

Kwang-Rok Kim

Jae Mok Lee

Jong Min Kim

Sung Dae Park

Nam Gee Kim

Seog Beom Song

Kil Woong Mo

Sun Mee Kim

Koun Ho Lee

Jang Hyuk Lee

Sun Chul Huh

Hye Jung Kang

Soon Ji Kwon

The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic syndromes such as diabetes, obesity, arteriosclerosis, hyperlipidemia, hyperinsulinism and hypertension, inflammatory diseases such as osteoporosis, liver cirrhosis and asthma, and cancer.

Indene derivatives and process for the preparation thereof

An indene derivative for selectively modulating the activities of peroxisome proliferator activated receptors (PPARs) having the following formula (I): wherein, or phenyl; being each unsubstituted or substituted with one or more substituents selected from the group consisting of halogen, CN, NH, NO, OR, phenyloxy, Calkyl, and Ccycloalkyl; and

Growing community of inventors

Daejeon, South Korea

Sung-Don Yang