Lg Chemical Ltd.

Sung-Chun Kim

Nakyen Choy

Heungsik Yoon

Hoil Choi

Chang-Sun Lee

Jong-Sung Koh

Young-Chan Son

Chung-Ryeol Kim

Chi-Hyo Park

The present invention relates to novel compounds of formula (I) which have inhibitory activity against human immunodeficiency virus ('HIV') protease, a process for the preparation thereof, and compositions for prevention or treatment of AIDS by HIV infection comprising the above compounds as active ingredients. ##STR1## wherein: R.sup.1 is an aromatic group, a nitrogen-containing aromatic group, C.sub.1-4 alkyl group optionally substituted with an aromatic group or a nitrogen-containing aromatic group, C.sub.1-4 alkoxy group optionally substituted with an aromatic group or a nitrogen-containing aromatic group;

Irreversible HIV protease inhibitors, compositions containing same and

The present invention relates to novel compounds of formula (I) which has inhibitory activities against human immunodeficiency virus ('HIV') protease, a process for the preparation thereof, and compositions for prevention or treatment of AIDS by HIV infection comprising the above compounds as active ingredients. ##STR1## wherein: R.sup.1 is an aromatic group, a nitrogen-containing aromatic group, C.sub.1-4 alkyl group optionally substituted with an aromatic group or a nitrogen-containing aromatic group, C.sub.1-4 alkoxy group optionally substituted with an aromatic group or a nitrogen-containing aromatic group;

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Daejeon, South Korea

Sung-Chun Kim