Osong Medical Innovation Foundation, Korea University Research and Business Foundation

Ewha University-Industry Collaboration Foundation

Samsung Life Public Welfare Foundation

Chong Kun Dang Pharmaceutical Corporation

Sung Chul Jung

Sang Hoon Lee

Han Su Kim

Young Bin Hong

Ji-Young Hwang

Yoon Shin Park

Yun Tae Kim

Byung-Ok Choi

So-Youn Woo

Yoon Mi Jin

Jin-Mo Park

Gyung Ah Kim

Inho Jo

Yesl Jun

Ha Yeong Kim

The present invention relates to a method for producing a spheroid form of tonsil-derived stem cells, the method enhances growth and differentiation efficiency of the tonsil-derived stem cells. The present method also produces a spheroid form of para-thyroid hormones. The method for producing a spheroid form of tonsil-derived stem cells enhances the proliferation rate of the stem cells per se and significantly increase differentiation potency into parathyroid cells.

Method for culturing differentiation-promoting and -sustaining spheroid form of tonsil-derived stem cells

The present invention relates to a HSP27 mutation (S135F) mediated Charcot-Marie-Tooth disease (CMT) animal model. Particularly, the vector expressing mutant HSP27 protein wherein the 135serine is substituted with phenylalanine has been injected in the mouse zygote and then the mouse harboring the expression vector was selected. The selected mouse was confirmed to display Charcot-Marie-Tooth disease phenotype, so that the animal model was expected to be efficiently used for the evaluation of the effect of Charcot-Marie-Tooth disease treating material candidates.

Animal model of Charcot-Marie-Tooth disease as HSP27 mutant (S135F) carrier

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Seoul, South Korea

Sung Chul Jung