Lg Life Sciences, Limited

Lg Chem, Ltd

Agency for Defense Development

Sung Bae Lee

Heui Sul Park

Hyoung Jin Kim

Soon Ha Kim

Seung Hyun Yoon

Hyo Shin Kwak

Sun Young Koo

Seung Yup Paek

Eok Park

Dong Ook Seo

Chul Woong Chung

Jeung Hie Choi

In Woo Kim

Sang Yong Hong

Deok Seong Park

Vasily Artemov

Won Hyung Lee

Eui Jung Choe

Kyoung Hee Kim

Sook Kyung Yoon

Suk Kyun Hong

Je Wook Chae

Mi Kyoung Cho

Suk Jun Youn

The present invention relates to a compound of Formula 1, a pharmaceutically acceptable salt or isomer thereof, a pharmaceutical composition including the same, and a use. The compound of Formula 1 according to the present invention has ketohexokinase (KHK) inhibitory activity, and is effectively used for preventing or treating metabolic disease such as diabetes, diabetic complications, obesity, nonalcoholic fatty liver disease, and fatty hepatitis.

3-azabicyclo[3,1,1]heptane derivative and pharmaceutical composition including same

The present application relates to an indole compound represented by formula (1): a pharmaceutically acceptable salt or isomer thereof, a composition for prevention or treatment of necrosis and necrosis-associated diseases, and a method for preparing the composition, the composition comprising the indole compound or the pharmaceutically acceptable salt or isomer thereof as an active ingredient.

Indole compound as inhibitor of necrosis

The present invention relates to a novel compound having GPR40 receptor agonist activity that promotes insulin secretion and inhibits blood sugar rise after glucose loading, and is thereby useful for the treatment of diabetes and complications thereof, the preparation method thereof and pharmaceutical composition containing them as an active ingredient.

GPR40 receptor agonist, methods of preparing the same, and pharmaceutical compositions containing the same as an active agent

The present invention relates to an indole amide compound represented by formula (1), a pharmaceutically acceptable salt or isomer thereof, a composition for prevention or treatment of necrosis and necrosis-associated diseases, and a method for preparing the composition, the composition comprising the indole compound or the pharmaceutically acceptable salt or isomer thereof as an active ingredient.

Indole amide compound as inhibitor of necrosis

The present invention relates to novel compounds of Formula 1 as sphingosine-1-phosphate receptor agonists which can be effectively used for the treatment of autoimmune diseases, a method for preparing the same, and a pharmaceutical composition comprising the same as an active component. The compounds according to the present invention are effective on extensive autoimmune diseases and chronic inflammatory diseases including relapsing-remitting multiple sclerosis, and can also be used for treating or preventing immunoregulation disorders.

Sphingosine-1-phosphate receptor agonists, methods of preparing the same, and pharmaceutical compositions containing the same as an active agent

The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.

Indole and indazole compounds as an inhibitor of cellular necrosis

Disclosed is a firearm having dual barrels comprising a firearm body which is equipped with a small caliber barrel and a large caliber barrel; a selector installed on one side of the firearm body to select the type of bullet and the mode of firing; a fire control system installed on the firearm body to enable aiming the target through detecting the target both at day and night time; a firearm switch unit installed on the firearm body to transmit the information on the firing of the bullet; a fuse setter installed on the firearm body to transmit the control signal of the fire control system to the fuse of the explosive bullet which is introduced into the large caliber barrel; and a sensor device unit installed on the firearm body to transmit the position of the selector and sensed firing signal to the fire control system.

Firearm having dual barrels

The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.

Indole compounds as an inhibitor of cellular necrosis

Disclosed are new compounds of formula (1) exhibiting excellent activity for glucokinase, pharmaceutical compositions having the same as an active ingredient, and a method of using the same as an active ingredient for lowering blood glucose level: in which the substituents are as defined herein.

Glucokinase activators and pharmaceutical compositions containing the same as an active ingredient

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Daejeon, South Korea

Sung Bae Lee