Ipca Laboratories Limited

Ipac Laboratories Limited

Suneel Yeshwant Dike

Ashok Kumar

Dharmendra Singh

Satish Rajanikant Soudagar

Nellithanath Thankachen Byju

Sandeep Madhavrao Burudkar

Chirag Hasmukh Shah

Avinash Manohar Nijasure

Prashant Gautam

Vijaya Bhaware

Vitthal Suryabhan Buchude

Pramil Kumar Mathur

Ashvini Saxena

Jaysingh Gehlot

Manavalan Saravanan

Brajesh Sharma

Gunjan Pramod Pathak

Byju Nellithanath Thankachen

Virendra Pal

Swapnil Shreekant Kore

Rahul Karde

Disclosed herein is a novel process for preparation of atovaquone. The process includes reacting 1,4-naphthoquinone with trans-4-(4-chlorophenyl) cyclohexane carboxylic acid followed by halogenation to obtain a dihalo-compound. Further, dehydrohalogenation of the dihalo-compound produces a monohalogeno-compound which under goes hydrolysis to produce atovaquone. The invention also discloses atovaquone in a substantially pure and well defined polymorphic form designated as 'Form IPCA-ATO,' and the preparation thereof.

Process for preparation of atovaquone and novel intermediates thereof

A process for the resolution of isomeric tramadol mixtures comprising: providing a purification stock comprising both cis and trans tramadol; contacting the purification stock with an acid under conditions effective to form an acid salt of the cis and trans tramadol in the purification stock; and separating the cis tramadol acid salt from the trans tramadol to obtain a purified cis tramadol acid salt; and optionally converting the cis tramadol acid salt to cis tramadol or to a pharmaceutically active salt thereof.

Tramadol recovery process

The preset invention relates to a cost effective, high yielding, reproducible method for the manufacture of alendronic acid or its salt, such as sodium alendronate, from inexpensive and readily available pyrrolidone using phosphonating agents such as PClin the presence of acids such as sulphonic acids, sulphuric acid or phosphoric acid, and pharmaceutical dosage forms of alendronic acid or pharmaceutically acceptable salts thereof.

Process for manufacture of 4-amino-hydroxybutylidene-1, 1-bisphosphonic acid and its salts

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Maharashtra, India

Suneel Yeshwant Dike