Dabur Research Foundation

Sunder Ramadoss

Manu Jaggi

Anand Vardhan

Mohammad Jamshed Ahmad Siddiqui

Praveen Rajendran

Mohammad Jamshed Ahmed Siddiqui

Achla Behl Khanna

Arvind Kumar Sharma

Mohammad Jamshed Siddiqui

The invention relates to the use of betulinic acid derivatives for the inhibition and or prevention of cancer growth. The invention also relates to novel betulinic acid derivatives useful for inhibition of tumor cancer cells and a process for the preparation of the derivatives. The invention also relates to anti-leukemic and anti-lymphoma activity of the betulinic acid derivatives, and the use of the derivatives for the treatment of prostate, lung, laryngeal, colon and ovarian cancer.

Betulinic acid derivatives for inhabiting cancer growth and process for the manufacture of betulinic acid

The invention relates to novel betulinic acid derivatives having antiangiogenic activity, processes for producing such derivatives and their use for treating tumor associated angiogenesis.

Betulinic acid derivatives having antiangiogenic activity, processes for producing such derivatives and their use for treating tumor associated angiogenesis

The invention provides novel paclitaxel derivatives obtained by effecting modifications at C , C and/or C positions of paclitaxel, said derivatives being useful in inhibiting the growth of cancer of lung, breast, ovary, cervix or leukemia, and pharmaceutical compositions comprising such derivatives.

Paclitaxel derivatives for the treatment of cancer

Extracting betulinic acid from Ziziphus jujuba

Use of betulinic acid and/or its derivatives for inhibiting and/or preventing angiogenesis is described. Compositions containing betulinic acid derivatives with or without betulinic acid can be used for these purposed.

Antiangiogenic activity of betulinic acid and its derivatives

The invention relates to the use of betulinic acid and its derivatives for the inhibition and/or prevention or cancer growth. The invention also relates to novel betulinic acid derivatives useful for the inhibition of tumor/cancer cells and a process for the preparation of the derivatives. The invention also relates to the antileukemic, and anti-lymphoma activity of the betulinic acid derivatives, and the use of the derivatives for the treatment of prostate, ovarian and lung cancer.

Use of betulinic acid derivatives for inhibiting cancer growth

A novel process for isolation of 10-deacetyl baccatin-III (10-DAB) and also complete separation of paclitaxel present in the primary extract, on a commercial scale from plant extract of Taxus species by solvent crystallization without employing chromatographic separation.

Process for isolation of 10-deacetyl baccatin-III

The invention relates to use of betulinic acid and/or its derivatives for treating, inhibiting, and/or preventing tumors or cancer growth more particularly, to treating leukemia, lymphomas, lung, prostate and ovarian cancer. This invention also relates to novel betulinic acid derivatives and a composition containing betulinic acid derivatives with or without betulinic acid.

Use of betulinic acid and its derivatives for inhibiting cancer growth

Novel process for isolation of 14.beta.-hydroxy 10-deacetyl baccatin-III (14.beta.-OH-DAB) on a commercial scale from plant extract by solvent crystallization without employing chromatographic separation.

Growing community of inventors

New Delhi, India

Sunder Ramadoss