Ssp Co. Ltd

Ss Pharmaceutical Co., Ltd.

Hisamitsu Medical Co., Ltd.

Sunao Takeda

Susumu Sato

Takemitsu Asaoka

Hiromichi Eto

Yasushi Kaneko

Minoru Tokizawa

Masaru Matsumoto

Kazuya Ishida

Kazunori Maebashi

Hideaki Matsuda

Fujiko Konno

Akihiro Shibata

Tadayuki Kuraishi

Naokata Taido

Ryuichi Kawahara

Haruyoshi Honda

Mari Ohtsuka

Yoshiyuki Takahashi

Kazuo Isomae

Koichi Tachibana

Fumio Ishii

Noriyuki Kawamoto

Terumitsu Kaihoh

Hiroyuki Hirota

Yoshihiro Nagao

Koji Kusano

Tasdayuki Kuraishi

Tadayoshi Taniyama

The invention is directed to an imidazole derivative represented by formula (1):wherein each of Rand Rrepresents an aryl group, a heteroaryl group, etc.; each of A, X, and Xrepresents N or CH; each of Y and Z represents O, S, etc.; each of R, R, and Rrepresents a hydrogen atom, an alkyl group, etc.; m is a number of 1 to 4; and n is a number of 0 to 4, or a salt thereof. The invention is also directed to a drug containing the derivative or the salt as an active ingredient. These compounds exert excellent effects of inhibiting production of NO and IL-6 and are useful for preventing or treating diseases induced by overproduction of NO and IL-6.

Imidazole derivatives or salts thereof and drugs containing the derivatives or the salts

Imidazole derivatives of the formula (1) or salts thereof, pharmaceuticals containing the derivatives or the salts, and intermediates for the synthesis of the derivatives or the salts (wherein R is lower alkyl; R is alkyl or aralkyl; and X is halogeno). These compounds exhibit G-CSF-like activities and can be substituted for G-CSF preparations.

Imidazole derivatives or their salts

The invention relates to a process for preparing a difluoroacetophenone derivative (4) by alkylthionating a compound (1) into a compound (2) and reacting this compound with a compound (3).

Preparation process of difluoroacetophenone derivative

Described is a triazole derivative represented by the formula (1):

Triazole derivative or salt thereof, preparation process thereof and pharmaceutical containing said compound as an effective ingredient

Triazole derivative or slat thereof, preparation process thereof and pharmaceutical containing said compound as an effective ingredient

Described is a triazole derivative represented by the formula (1): ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an aralkyl group, X.sup.1 and X.sup.2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a halogenoalkyl and n stands for an integer of 0 to 2, or salt thereof; a preparation process of said compound and a pharmaceutical comprising said compound as an effective ingredient. The compound as described above has high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.

Triazole derivative or salt thereof, preparation process thereof and

A compound having formula (2): ##STR1## wherein R represents hydrogen, a straight or branched C.sub.1-10 alkyl group, a C.sub.7-11 aralkyl group or a C.sub.2-10 carboacyl group and m stands for 1 to 5.

Triazole derivative or salt thereof

Described is a triazole derivative represented by the formula (1): wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an aralkyl group, X.sup.1 and X.sup.2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a halogenoalkyl and n stands for an integer of 0 to 2, or salt thereof; a preparation process of said compound and a pharmaceutical comprising said compound as an effective ingredient. The compound as described above has high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.

Triazole derivative or salt thereof preparation process thereof, and

Described is a triazole derivative represented by the formula (1): ##STR1## wherein R.sup.1 represents a lower alkyl group or an aralkyl group, R.sup.2 represents a hydrogen atom, a lower alkyl group, an aralkyl group or an acyl group, X.sup.1 and X.sup.2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a trifluoromethyl group, n stands for an integer of 0 to 2 and m stands for an integer of 1 to 5, or salt thereof; and also a pharmaceutical comprising the derivative or salt thereof as an effective ingredient. The compound as described above has a high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.

Described is a triazole derivative represented by the formula (1) or salt thereof, preparation process thereof, preparation intermediates represented by the formulas (2) and (3), and a pharmaceutical comprising the compound represented by the formula (1) or salt thereof. ##STR1## wherein n stands for 0, 1 or 2, X.sup.1 represents H or F and Y.sup.1 and Y.sup.2 each independently represents H, halogen or CF.sub.3.

Triazole derivative, preparation process thereof and pharmaceutical

Described is a triazole derivative represented by the formula (1) or salt thereof, preparation process thereof, preparation intermediates represented by the formulas (2) and (3), and a pharmaceutical comprising the compound represented by the formula (1) or salt thereof. wherein n stands for 0, 1 or 2, X.sup.1 represents H or F and Y.sup.1 and Y.sup.2 each independently represents H, halogen or CF.sub.3.

Triazole derivative and pharmaceutical comprising the same as an

Described is a triazole derivative represented by the formula (1): wherein R represents a hydrogen atom, an alkyl group, an aralkyl group or an acyl group, n stands for 0 to 2 and m stands for 1 to 5 or salt thereof, and a pharmaceutical containing the derivative or salt as an effective ingredient.

Growing community of inventors

Ichihara, Japan

Sunao Takeda