Northwestern University

University of California

Chapman University

Sun Yang

Richard B Silverman

Fengtian Xue

Haitao Ji

Frank L Meyskens

Thomas L Poulos

Keykavous Parang

Frank L Meyskens, Jr

Richard Chamberlin

Apurinic/apuyrimidinic endonuclease 1/Redox Factor-1 (APE/Ref-1) inhibitors are provided along with methods of using the same. The inhibitor has the structure of Formula I: or a pharmaceutically acceptable salt thereof. n is an integer from 4 to 14, X and X' are each independently H or OH, and Y and Y′ are each independently H or OH.

APE/REF1 inhibitors for the treatment of cancer

Disclosed herein are methods and compositions for administering immunotherapy to a subject in need thereof and for treating a subject in need thereof, where in the methods the subject is administered an effective amount of an inhibitor of nNOS for inducing an immunotherapeutic response in the subject and for treating the subject. The disclosed methods and composition may be utilized for treating a subject having a cell proliferative disease or disorder such as melanoma.

Use of neuronal nitric oxide synthase inhibitors for immunotherapy in melanoma patients

Methods for melanoma treatment and prevention with selective nitric oxide synthase inhibitor compounds and related pharmaceutical compositions, alone or in conjunction with one or more other melanoma therapies.

Specific nNOS inhibitors for the therapy and prevention of human melanoma

Inhibitors of nitric oxide synthase for treatment of melanoma

Growing community of inventors

Foothill Ranch, CA, United States of America

Sun Yang