St Pharm Co., Ltd.

Dong-a Pharmaceutical Co., Ltd

Hyosung Chemical Corporation

Sun Ki Chang

Geun Jho Lim

Chang Ho Byeon

Hyun Woo Baek

Geun Gho Lim

Moon Soo Kim

Yeong Hun Kim

Hoe Jin Yoon

Tae Hyun Yoon

Jae Hun Kim

Moohi Yoo

Woo Young Kwak

Heung Jae Kim

Jong Pil Min

Hong Jun Kim

Seok Hun Woo

Changho Byeon

Seokhun Woo

Moonsu Kim

Seongsu Jeong

Junwon Lee

Hoejin Yoon

Jongmoon Park

Min Kyu Kim

Sun Kue Kim

Ji Hwan Choi

In Hyeok Baek

Jong Moon Park

Hae Souk Cho

Jae Yoon Shim

Sang Kyu Kang

Hyeon Jin Lee

YunHee Choi

Jun Hyun Oh

The present invention provides a novel method for preparing high-purity gadobutrol or hydrates thereof. The preparation method of the present invention can have an advantage of simplifying a process by forming a gadolinium complex in-situ without purification of a butrol intermediate and omitting a resin purification process unlike a conventional method for synthesizing gadobutrol. In addition, the preparation method of the present invention can be used to produce high-purity gadobutrol or hydrates thereof at a high yield only through the simple process as above, and thus can be useful in mass production.

Method for preparing gadobutrol

The present disclosure provides a method for preparing ((2,2-dimethyl-1,3-dioxane-5,5-diyl)bis(methylene))bis(bis(2-methoxyphenyl)phosphine), a ligand for a polyketone polymerization catalyst, under mild conditions with high purity and high yield. Therefore, the preparation method of the present disclosure can be easily applied to mass production.

Method for preparing ligand for polyketone polymerization catalyst

Disclosed is a method of preparing an intermediate for an oxazolidinone derivative, which enables 5-bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine to be produced at high yield and high purity, thus exhibiting high preparation efficiency under optimal processing conditions and making it suitable for industrial mass production.

Preparation method of intermediate for oxazolidinone derivative

The present invention relates to a novel method for preparing (S)&#x2014;N-(2-aminoethyl)-3-(4-alkoxyphenyl)propane-1,2-diamine trihydrochloride.

Method for preparation of (S)-N1-(2-aminoethyl)-3-(4-alkoxyphenyl)propane-1,2-diamine trihydrochloride

Provided are a novel polyketone polymerization catalyst and a method of preparing a ligand, which can reduce production costs and can enable commercial mass synthesis by using ((2,2-dimethyl-1,3-dioxane-5,5-diyl)bis(methylene))bis(bis(2-methoxyphenyl)phosphine) as a ligand constituting the polykeytone polymerization catalyst, the ligand having a simple structure and a small molecular weight while having high activity.

Polyketone polymerization catalyst

The present disclosure relates to a novel method for preparing high-purity gadobutrol. The present disclosure can be easily applied to a large scale production because purity of intermediate can be managed via simple and mild process and accordingly, high-purity or ultra high-purity gadobutrol that has higher purity than previous gadobutrol can be prepared in high yield therethrough.

Disclosed is a novel method of preparing highly pure calcobutrol using an intermediate (butrol) of gadobutrol without using highly pure gadobutrol. This method is capable of obtaining calcobutrol at high purity and high yield through a simple and environmentally friendly process, and thus can be easily applied to mass production.

Method for preparing calcobutrol

The present invention provides a novel method for preparing lacosamide with high chiral purity from D-serine. The method of the present invention can obtain lacosamide with high chiral purity in a high yield through a simple and environmentally-friendly process and thus can be easily applied to mass production.

Method for preparing lacosamide

The present invention relates to an improved method for preparing dipeptidyl peptidase-IV inhibitor intermediates. The present invention is able to reduce preparation costs by using low cost reagents on reaction and is able to be used in mass production by improving yield.

Method for preparing dipeptidyl peptidase-IV inhibitor and intermediate

The present invention provides a method which enables the simple, economical and high-yield production which is a key intermediate of antidiabetic drug Januvia.

Preparation method of intermediate of sitagliptin

Growing community of inventors

Gyeonggi-do, South Korea

Sun Ki Chang