Dong-a St Co., Ltd.

Cj Cheiljedang Corporation

Dong-a Pharm. Co., Ltd.

Sun-Ho Choi

Min-Jung Lee

Weon-Bin Im

Sung-Hak Choi

Soon-Hoe Kim

Hyun-Jung Sung

Jung-Sang Park

Mi-Yeon Kim

Kang-Hun Cho

Chong-Hwan Cho

Ji-Hoon Choi

Ji-Su Kim

Woo Young Kwak

Jin-Hyuk Kim

Min-seok Choi

Chang-Yong Shin

Hyung-Keun Lee

Seung-Hyun Song

Cheon-Hyoung Park

Yoon-Jung Kim

Jun-Hwan Moon

Ho-Sang Moon

Ju-Hee Sohn

Tae-Kyoung Sohn

Punna Reddy Ullapu

Han-joo Kim

The present invention relates to a novel salt of (R)-(1-methylpyrrolidine-3-yl)methyl(3'-chloro-4&#x2032;-fluoro-[1,1&#x2032;-biphenyl]-2-yl)carbamate and a crystal form thereof. Also, the novel salt of (R)-(1-methylpyrrolidine-3-yl)methyl(3&#x2032;-chloro-4&#x2032;-fluoro-[1,1&#x2032;-biphenyl]-2-yl)carbamate and the crystal form thereof according to examples of the present invention have remarkably excellent stability, hygroscopicity and solubility.

Salt of (R)-(-methylpyrrolidine--yl)methyl(-chloro--fluoro-[-biphenyl]--yl)carbamate and crystal form thereof

The present disclosure relates to a novel tetrahydropyridine derivative compound, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, methods for preparing the compounds, methods for inhibiting UDP-3-O&#x2014;(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC), methods for treating Gram-negative bacterial infections, the use of the compounds for the preparation of therapeutic medicaments for treating Gram-negative bacterial infections, and pharmaceutical compositions for prevention or treatment of Gram-negative bacterial infections, which contain the compounds. The compounds represented by formula I, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present disclosure can exhibit excellent effects on the treatment bacterial infections.

Tetrahydropyridine derivatives and their use as antibacterial agents

Provided are biphenyl derivatives having the structure of Formula 1: stereoisomers thereof, and pharmaceutically acceptable salts thereof, wherein Ris hydrogen, halogen, hydroxy, substituted or unsubstituted C-Calkyl, or C-Calkoxy; R, Rand Rare each independently hydrogen, halogen, substituted or unsubstituted amino, nitro, cyano, hydroxy, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkoxy, or &#x2014;C(O)R; Ris hydrogen or C-Calkyl; n is 0 or 1; and Ris hydrogen or amino, methods for preparing the same, and a pharmaceutical composition containing the same. The biphenyl derivatives having the structure of Formula 1 act as muscarinic M3 receptor antagonists, and thus are useful for the prevention or treatment of a disease selected from among chronic obstructive pulmonary disease, asthma, irritable bowel syndrome, urinary incontinence, rhinitis, spasmodic colitis, chronic cystitis, Alzheimer's disease, senile dementia, glaucoma, schizophrenia, gastroesophageal reflux disease, cardiac arrhythmia, and hyper-salivation syndromes.

Biphenyl derivatives and methods for preparing same

The present invention provides a novel benzamide derivative or a pharmaceutically acceptable salt thereof, a method for preparing the same, and a 5-HTreceptor agonist containing the same as an active ingredient. Benzamide derivatives of the present invention have a superior affinity for 5-HTreceptors, a capability to reduce a gastric emptying time and a low toxicity, and consequently are therapeutically effective for the treatment of a variety of diseases associated with 5-HTreceptors.

Benzamide derivatives

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Seoul, South Korea

Sun-Ho Choi