Il-Yang Pharm. Co., Ltd

Ctc Bio, Inc.

Sun-Ahe Lee

Yong-Seok Kim

Dong-Yeon Kim

Bong-Sang Lee

Do-Woo Kwon

Dae-Jin Cho

Gong-Yeal Lee

Hong-Youb Kim

Seok-Hun Woo

Byoung-Cheol Han

Hong-Ryeol Jeon

Seong-Shin Kwak

Hyun-Jung Park

Jae-Gun Kim

Woo-Chul Bae

Jeong-Hwa Yoo

The present invention relates to an N-phenyl-2-pyrimidine-amine derivative showing a superior effect on lung cancer, gastric cancer, colon cancer, pancreatic cancer, hepatoma, prostatic cancer, breast cancer, chronic or acute leukemia, hematologic malignancy, encephalophyma, bladder cancer, rectal cancer, or cervical cancer, etc. of warm-blooded animals and its salt. The present invention also relates to a process for preparing the compound, and to a pharmaceutical composition for the treatment of the above various diseases, which comprises an effective amount of the compound as an active ingredient together with pharmaceutically acceptable inert carriers.

N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof

The present invention relates to a novel N-phenyl-2-pyrimidine-amine derivative represented by the above formula (1) and its salt showing a superior effect on cancer in warm-blooded animals, such as lung cancer, gastric cancer, colon cancer, pancreatic cancer, hepatoma, prostatic cancer, breast cancer, chronic or acute leukemia, hematologic malignancy, encephalophyma, bladder cancer, rectal cancer, cervical cancer, lymphoma, etc. The present invention also relates to a process for preparing the compound, and to a pharmaceutical composition for the treatment of the above various diseases, which comprises an effective amount of the compound as an active ingredient together with pharmaceutically acceptable inert carriers.

Growing community of inventors

Suwon, South Korea

Sun-Ahe Lee