The Brigham and Women's Hospital, Inc.

Beth Israel Deaconess Medical Center, Inc.

Dana-farber-cancer Institute Inc.

Sumone Chakravarti

Vijay K Kuchroo

Terry Barton Strom

Xin Xiao Zheng

Catherine Anne Sabatos-Peyton

Chen Zhu

Eugene K Cha

Alberto Sanchez-Fueyo

Gordon James Freeman

Catherine Sabatos

Jennifer Meyers

The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods useful for promoting or inhibiting antigen-presenting cell (APC) activation. The invention is related to discovery of functional characteristics of TIM-3, a molecule that is preferentially expressed on the surface of Th1 cells. The methods are useful for treating disorders including cancer, infectious disease, allergy, asthma, and autoimmune disease.

Methods related to TIM 3, a TH1-specific cell surface molecule, for activating antigen presenting cells

The invention relates to isolated polypeptides and nucleic acids encoding polypeptides which comprise a tim-3 IgV domain and a tim-3 intracellular domain, wherein the polypeptides do not comprise a tim-3 mucin domain or a tim-3 transmembrane domain. In addition, the invention relates to methods of modulating immune responses in a subject, comprising administering to the subject a therapeutically effective amount of an agent that modulates tim-3 activity. Immune responses include, but are not limited to, immune tolerance, transplantation tolerance, Th1 responses and Th2 responses.

TIM-3 ligands and methods of modulating immune responses

Tim-3 ligands and methods thereof

The invention relates to methods of modulating immune responses in a subject, such as by administering to the subject agents which modulate tim-1, tim-2 or tim-4 activity, or which modulate the physical interaction between tim-1 and tim-4 or between tim-2 and a tim-2 ligand. Immune responses include, but are not limited to, autoimmune disorders, transplantation tolerance, and Th1 and Th2-mediated responses and disorders. The invention also relates to novel assays for identifying agents which modulate the physical interaction between tim-1 and tim-4. In addition, the invention relates to novel soluble tim-4 polypeptides and to nucleic acids which encode them.

Methods of modulating immune responses by modulating tim-1, tim-2 and tim-4 function

Growing community of inventors

Victoria, Australia

Sumone Chakravarti