Other

University of Massachusetts

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Atlantic Pharmaceuticals, Inc.

Atlantic Technology Ventures, Inc.

Sumner H Burstein

Raphael Mechoulam

Aviva Breuer

Robert B Zurier

William Devane

Lawrence Recht

N-fatty acid-amino acid conjugates and Jprostanoid-amino acid conjugates are disclosed along with methods for making such conjugates and methods of using these conjugates in the treatment of conditions that involve dysfunctional lipid metabolism, insulin sensitivity, glucose homeostasis, and/or inflammation.

Lipid-amino acid conjugates and methods of use

The invention relates to the use of cannabinoid compounds (derivatives of tetrahydrocannabinol) for decreasing cell proliferation in a mammal.

Cannabinoid drugs

The present invention relates to non-psychoactive derivatives of tetrahydro-cannabinol, which exhibit anti-inflammatory, analgesic and leukocyte antiadhesion activities. The invention includes novel derivatives of (3R,4R)-&Dgr; -tetrahydrocannabinol-11-oic acids &lsqb;hereinafter referred to as (3R,4R)-&Dgr; -THC-11-oic acid&rsqb;, as well as pharmaceutical compositions containing the (3R,4R)-&Dgr; -THC-11-oic acid derivatives. The invention further covers methods of administering the novel derivatives and pharmaceutical compositions as therapeutic agents in the treatment of pain and tissue inflammation. Non-psychoactive derivatives of &Dgr; -THC-11-oic acid are described which have analgesic and anti-inflammatory properties.

(3R,4R)-&Dgr;8-tetrahydrocannabinol-11-oic acids useful as antiinflammatory agents and analgesics

The present invention relates to non-psychoactive derivatives of tetrahydro-cannabinol, which exhibit anti-inflammatory, analgesic and leukocyte antiadhesion activities. The invention includes novel derivatives of (3R,4R)-.DELTA..sup.8 -tetrahydrocannabinol-11-oic acids [hereinafter referred to as (3R,4R)-.DELTA..sup.8 -THC-11-oic acid], as well as pharmaceutical compositions containing the (3R,4R)-.DELTA..sup.8 -THC-11-oic acid derivatives. The invention further covers methods of administering the novel derivatives and pharmaceutical compositions as therapeutic agents in the treatment of pain and tissue inflammation. Non-psychoactive derivatives of .DELTA..sup.8 -THC-11-oic acid are described which have analgesic and anti-inflammatory properties.

(3R,4R)-.DELTA..sup.8 -tetrahydrocannabinol-11-oic acids useful as

(3S,4S)-delta-6-tetrahydrocannabinol-7-oic acids and derivatives

The invention relates to compounds of the formula ##STR1## having the (3S,4S) configuration and being essentially free of the (3R,4R) enantiomer, in which A--B indicates an optional 1(2) or 6(1) double bond, X is carboxy, carbalkoxy, or carboxamido, linked to the ring directly or through an alkylene linkage, G is halogen, alkyl, or oxy, and Y is alkyl, oxy, or oxyalkylene. The invention further relates to the synthesis of such compounds, and to pharmaceutical compositions and therapeutic methods in which such compounds may be employed.

Certain tetrahydrocannabinol-7-oic acid derivatives

Non-psychoactive derivatives of .DELTA..sup.6 -THC-7-oic acid are described which have analgesic and anti-inflammatory properties.

(3R,4R)-.DELTA..sup.6 -tetrahydrocannabinol-7-oic acids useful as

6a,7,10,10a-tetrahydro-6,6-dimethyl-9-carboxyl-3-pentyl-6-H-dibenzo [b,d] pyran-1-ol is a potent antagonist to endogenous platelet activating factor (PAF). PAF is a factor in many of the pathological manifestations of disease, allergy or injury, such as inflammation, thrombosis and anaphylaxis. The actions of PAF can be inhibited in vivo by the present composition, thereby providing a safe and effective treatment for PAF-induced disorders.

Platelet activating factor antagonist and methods of use therefor

A non-psychoactive metabolite of THC is described. The invention is based on the discovery that this metabolite has analgesic and anti-inflammatory properties. The use of the metabolite as a therapeutic agent is based upon the further discovery that it is non-ulcerogenic.

Growing community of inventors

Framingham, MA, United States of America

Sumner H Burstein