Mogam Institute for Biomedical Research

Mogam Biotechnology Institute

Sumin Lee

Jae Hyun Park

Seongtae Yun

Hyung-Kwon Lim

Mi Jung Lee

Dong-Sik Kim

Young Seoub Park

Kisu Kim

Jae Chan Park

Heechun Kwak

Mee Sook Oh

Sungho Hwang

Ki Joon Cho

SungHo Hwang

Junhong Jeong

Jung-Seob Kim

Provided is an expression vector having an improved ability to express a gene. Also provided are cells transformed by the expression vector and a method for mass-producing a target protein by using the cells. The expression vector contains a simian virus 40 promoter, a scaffold attachment region or matrix attachment region element, and a chimeric intron. The vector shows an improved ability to express a gene, and thus, can attain a significantly increased expression of a heterogeneous gene.

Expression vector for expressing heterogeneous gene

The present invention relates to an antibody that binds specifically to a tissue factor pathway inhibitor (TFPI), a nucleic acid encoding the antibody, a vector comprising the nucleic acid, a host cell transformed with the vector, a method for producing the antibody, and a pharmaceutical composition for treating hemophilia, which comprises the antibody as an active ingredient. The antibody of the present invention, which binds specifically to TFPI, can activate the extrinsic pathway of blood coagulation by inhibiting TFPI. Thus, the antibody of the present invention can be effectively used for the treatment of antibody-induced hemophilia patients and for the prevention of blood coagulation disease in hemophilia-A or hemophilia-B patients.

Antibody binding to TFPI and composition comprising the same

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Yongin-si, South Korea

Sumin Lee