Fujisawa Pharmaceutical Company, Ltd.

Teijin Limited

Sumihisa Kimura

Takehisa Hata

Satoshi Ueda

Saburo Murata

Fumio Shimojo

Akira Kagayama

Takeo Hirose

Yuji Makino

Atsuo Hazato

Rinta Ibuki

Sotoo Asakura

Yuji Tokunaga

Kazutake Kado

Norio Ohnishi

Sachiyo Tanimoto

Nobuaki Hanajima

Tamotsu Koyama

Toshiaki Takeda

Yoshiko Ohishi

To provide a pharmaceutical composition comprising a water-insoluble active substance, surfactant(s) and solid carrier(s), which is improved in dissolution and oral absorption characteristics.

Medicinal composition

Provided is a medicinal composition having a very satisfactory drug release profile and a very satisfactory drug absorption profile after oral administration characterized by its comprising an insoluble drug and two or more surfactants, at least one of the surfactants having as dissolved therein the insoluble drug and the other surfactant or surfactants.

Two surfactant-containing medicinal composition

Percutaneously absorbable preparation

External skin treatment agent composition containing isocarbacyclins as

The invention relates to a delayed action preparation which comprises a core comprising a drug and a swelling agent and an outer membrane comprising a biodegradable high molecular weight substance characterized in that the swelling agent is contained in a sufficient amount to cause a explosion of the outer membrane of biodegradable high molecular weight substance at a definite time after administration. This preparation provides for free control over the timing of drug release and is suited for administration not only by the oral route but also by the intramuscular, subcutaneous and other routes.

Delayed action preparation

Sustained release medicinal preparation

Growing community of inventors

Kawanishi, Japan

Sumihisa Kimura