Nikkiso Company Limited

Sumiaki Matsuo

Kunihiko Akita

Fumihiko Ishizaki

Hiroaki Mochizuki

Hiroyuki Kawajiri

Satoru Kawarabayashi

Kazumi Yokoyama

Harutoshi Okabe

Tadashi Iwahori

A blood purification apparatus is provided in which waste liquid is prevented from flowing through an ultrafiltration pump during ultrafiltration so that the performance and accuracy of ultrafiltration can be maintained over a long period. The blood purification apparatus includes an ultrafiltration line one end of which is connected to a dialysate introduction line at a position on a downstream side with respect to a duplex pump. The ultrafiltration line is provided with the ultrafiltration pump. The ultrafiltration pump is capable of performing ultrafiltration by drawing dialysate in the dialysate introduction line through the ultrafiltration line such that the volume of the dialysate to be introduced into a dialyzer becomes smaller than the volume of waste liquid to be drained from the dialyzer.

Blood purification apparatus

A dialysis base unit that is provided separately from a dialysate supply device for delivering dialysate and performs hemodialysis using the dialysate delivered from the dialysate supply device. The dialysis base unit includes a dialysate supply device identifying unit capable of identifying the dialysate supply device connected to the dialysis base unit. A dialysis system includes the dialysate supply device for delivering dialysate and the dialysis base unit.

Dialysis base unit and dialysis system

A tube connector is configured to connect between a main tube and a peristaltically-actuated tube. The tube connector includes a first connection part configured to be connected to the main tube; a second connection part configured to be connected to the peristaltically-actuated tube; a communication part being provided between the first connection part and the second connection part and having a communication flow path for communicating between a first flow path through which fluid flows in the first connection part and a second flow path through which the fluid flows in the second connection part; and a main body section. The first flow path and the second flow path are formed to have a constant diameter and are formed so as to extend along the axial direction of the main body section. A diameter of the first flow path is smaller than a diameter of the second flow path. The communication flow path is formed so as to gradually enlarge in diameter from a first flow path side to a second flow path side. A central axis of the first flow path and a central axis of the second flow path are shifted toward the radial direction of the main body section.

Tube connector, extracorporeal circulation circuit, and blood purification device

There is provided a blood purification apparatus with which the efficiency of dialysate purification can be improved and the reduction in the amount of electrolytes contained in dialysate and necessary for treatment can be suppressed. The blood purification apparatus includes a storage device capable of storing a predetermined amount of dialysate that is necessary for blood purification treatment, a dialysate circulation line through which the dialysate is allowed to circulate by introducing the dialysate in the storage device into the dialyzer and draining waste liquid from the dialyzer into the storage device, and the dialysate purification device that purifies the dialysate in the dialysate circulation line. A treatment state in which the dialysate is allowed to be introduced into the dialyzer without flowing through the dialysate purification device and a purification state in which the dialysate is allowed to be purified by the dialysate purification device are taken switchably.

A dialysate-extracting apparatus is provided in which scattering of dialysate that may occur when an opening-and-closing device is detached from a collecting port can be prevented and the cleanliness of the collecting port can be assuredly maintained. The dialysate-extracting apparatus includes a dialysate-extracting device connected to a dialysate flow route and having a collecting port from which dialysate flowing in the dialysate flow route is collectable, and an opening-and-closing device detachable from and attachable to the dialysate-extracting device in such a manner as to open and close the collecting port and including a seal portion that seals the collecting port in a closed state. When the opening-and-closing device is detached from the dialysate-extracting device, a part of the opening-and-closing device that is on an inner side with respect to the seal portion is bendable and displaceable toward the collecting port.

Dialysate-extracting apparatus

A blood purification apparatus comprising: a blood circuit including an arterial blood circuit and a venous blood circuit and that is capable of extracorporeally circulating blood of a patient from a distal end of the arterial blood circuit to a distal end of the venous blood circuit; a blood purification device provided between the arterial and the venous blood circuit of the blood circuit and that is capable of purifying the blood flowing in the blood circuit; a dialysate introduction line for introducing dialysate into the blood purification device and a dialysate drain line for discharging drain liquid from the blood purification device; a liquid delivery pump provided to the dialysate introduction line and that is capable of causing the dialysate in the dialysate introduction line to flow; a heating device that is capable of heating the dialysate to be introduced from the dialysate introduction line into the blood purification device; a temperature-detecting device that is capable of detecting a temperature of the dialysate heated by the heating device; and a control device that is capable of controlling at least the liquid delivery pump and the heating device, wherein the control device is configured so that, if a dialysate temperature detected by the temperature-detecting device is higher than or equal to a predetermined value, the liquid delivery pump is controlled to cause the dialysate in the heating device to flow to an upstream side or a downstream side with respect to the heating device without allowing the dialysate to be introduced into the blood purification device.

A peristaltic pump includes a mounting concave sectionon which a peristaltically-actuated tube connected to an arterial blood circuit is mountable; a roller which compresses the peristaltically-actuated tube mounted on the mounting concave section in a radial direction and causes the peristaltically-actuated tube to be peristaltically actuated in a longitudinal direction such that a liquid therein is flowable in the arterial blood circuit; a load sensor that is able to detect displacement of the peristaltically-actuated tubemounted on the mounting concave section in the radial direction; and blockage detecting means that is able to detect a blockage of the arterial blood circuit based on the displacement detected by the load sensor.

Peristaltic pump

A pressure detection device of a liquid flow route includes; displacement detecting means that detects displacement of a peristaltically-actuated tube in the radial direction; pressure calculating means that is able to calculate blood removal pressure based on the displacement of the peristaltically-actuated tube; closed flow route forming means that is able to form a closed flow route which includes a portion at which the displacement detecting means is disposed; pressure changing means that is able to arbitrarily change the pressure in the closed flow route; pressure detection means that is able to detect pressure change in the closed flow route; and calibration curve acquiring means that is able to produce and acquire a calibration curve with which the displacement detecting means and the pressure calculating means are calibrated by a relationship between the pressure change detected by the pressure detection means and a detection value of the displacement detecting means.

Pressure detection device of liquid flow route

A pressure detection device of a liquid flow route is provided which detects a pressure of an arterial blood circuit consisting of a flexible tube, a portion of which is connected to a peristaltically-actuated tube that can cause an internal liquid to flow by being compressed in a radial direction and being peristaltically actuated in a longitudinal direction in a roller of a blood pump, and which enables a predetermined liquid to be circulated. The pressure detection device includes a load sensor that detects radial displacement of the peristaltically-actuated tube.

Growing community of inventors

Shizuoka, Japan

Sumiaki Matsuo