Sanaria Inc.

Johns Hopkins University

The Rockefeller University

Sumana Chakravarty

Stephen L Hoffman

Russell H Taylor

Iulian Ioan Iordachita

Moriya Tsuji

Gregory Chirikjian

Balazs Peter Vagvolgyi

Jin Seob Kim

Can Kocabalkanli

Joshua D Davis

Michelle Laskowski

Brian K Chirikjian

Ting Da

John S Chirikjian

Amanda Canezin

Henry Phalen

Hongtao Wu

Mariah Schrum

Mengdi Xu

Shengnan Lu

Michael Aaron Pozin

Systems and methods for providing a combined mosquito staging and dissection system are disclosed. The system can include a mosquito staging subsystem; a robotic pick-and-place station; and a dissection, extrusion, collection, and disposal subsystem. The subsystems can include one or more stations to provide orientation, decapitation, extrusion of salivary glands, and disposal of carcasses of the mosquitoes. The resident live sporozoites from the salivary glands can be used to produceSPZ-based vaccines.

Apparatus and method of use for an automated mosquito salivary gland extraction device

A device and method of use for augmenting the extraction of salivary glands from-infected mosquitoes, where the sporozoite stage ofprimarily resides. Sporozoites are useful for research as well as for the immunogen in whole parasite vaccines for the prevention of malaria. The device and methods of use disclosed herein greatly increase the rate at which sporozoites can be harvested.

Mosquito salivary gland extraction device and methods of use

Disclosed herein are pharmaceutical compositions comprisingsporozoite-stage parasites and compatible glycolipid adjuvants useful in vaccines for preventing or reducing the risk of malaria. In particular, human host rangeand analogues of &#x3b1;-galactosylceramide (&#x3b1;-GalCer), a ligand for natural killer T (NKT) cells, are combined in pharmaceutical compositions, which are useful as vaccines against malaria. Methods of use are also provided.

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Growing community of inventors

Derwood, MD, United States of America

Sumana Chakravarty