Zoetis Services LLC

The University of Melbourne

Suman Mahan

Paul Joseph Dominowski

Duncan Mwangi

Dennis L Foss

Sharath K Rai

Shaunak Vora

John Morgan Hardham

Richard Lee Krebs

Sangita Mediratta

Lauren Wilmes

Sarah A Salmon

Kaori Mohr

Sandra Ann Marie Lightle

Guillermo Gallo

Joseph Michael Bricker

Glenn Francis Browning

Philip Francis Markham

Laurel Mary Sly

Traci K Godbee

Fred H Weber

Marc Serge Marenda

Sandra Ann Lightle

Julie Lydia Fitzpatrick

Michael Christopher Fontaine

Anita Dorota Jaglarz

William Donachie

David George Smith

The invention provides a substantially antigen-free composition for induction of innate immune response in a bird or a mammal, the composition comprising a saponin, a sterol, a quaternary amine, and a polyacrylic polymer to the mammal or bird. Methods of using the composition are also provided.

Methods and composition for induction of immune response

The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.

Oil-based adjuvants

Disclosed herein areimmunogenic compositions useful in raising an immune response in animals against. Also disclosed herein are methods for generating a protective response against infections in mammals caused by

compositions

Methods and compositions for induction of immune response

The invention provides a liposomal adjuvant composition comprising an external membrane and an internal compartment, the external membrane comprising: a quaternary ammonium compound; a sterol; a phospholipid; and a glycolipid. Vaccine compositions comprising the liposomal adjuvant of the instant invention are also provided.

Liposomal adjuvant compositions

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Kalamazoo, MI, United States of America

Suman Mahan