Xenon Pharmaceuticals Inc.

Genentech, Inc.

Novartis Ag

Sultan Chowdhury

Shaoyi Sun

Christoph Martin Dehnhardt

Qi Jia

Alla Yurevna Zenova

Michael Edward Grimwood

Jianmin Fu

Thilo Focken

Mikhail A Chafeev

Ivan William Hemeon

Serguei Sviridov

Brian Salvatore Safina

Shifeng Liu

Nagasree Chakka

Jean-Christophe Andrez

Daniel P Sutherlin

Rajender Kamboj

Jianyu Sun

Duanjie Hou

Michael Scott Wilson

Zaihui Zhang

Vishnumurthy Kodumuru

Jean-Jacques Alexandre Cadieux

Vandna Raina

Paul Robert Bichler

Daniel Fred Ortwine

Kristen Nicole Burford

Mark Wood

Philippe Bergeron

Mehran Seid Bagherzadeh

Jonathan David Langille

Robert Joseph Devita

Simon James Gauthier

Jun M Li

Steven McKerrall

Jian-Min Fu

Melwyn A Abreo

Mark W Holladay

Michael D Winther

Heinz W Gschwend

Chi Tu

Wenbao Li

Jiuxiang Zhu

Natalie Alysia Dales

Natalia Pokrovskaia

Tao Wang

David Earl Bogucki

Tarek Suhayl Mansour

Kwong Wah Lai

Daniel F Harvey

Tom Hsieh

Shannon Marie Decker

Abid Hasan

Lauren Fraser

Tao Sheng

Wei Gong

Syed Abid Hasan

Robert Fraser

Zhiguo Liu

James Philip Johnson, Jr

James Roy Empfield

Stefanie Abel

Emad El-Sayed

Elke Huthmann

Thomas Isarno

Amy Frances Douglas

Zoran Cikojevic

Charles Jay Cohen

Sengen Sun

Andrew D White

Mehran Bagherzadeh

Julia Fonarev

Chien-an Chen

Chien-An Chen

Mikhail Kondratenko

Cindy J Hudson

Kashinath Sadalapure

Dan Sutherlin

Teresa Phuongtram Nguyen

Qi Ji

Mikhail A Kondratenko

Jian-min Fu

James Philip Johnson

Mikhail Chafeev

Jun Li

Mikhail Chafev

Jr Johnson James Philip

This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.

Benzenesulfonamide compounds and their use as therapeutic agents

The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R, R, subscript n, ring A, X, L, subscript m, X, ring B, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Substituted benzamides and methods of use thereof

This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.

Benzenesulfonamide compouds and their use as therapeutic agents

The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables R, R, subscript n, subscript q, ring A, X, L, subscript m, X, R, R, R, R, R, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Therapeutic compounds and methods of use thereof

The invention provides compounds having the general formula (I): and pharmaceutically acceptable salts thereof, wherein the variables R, R, n, ring A, X, L, m, R, R, R, R, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

Substituted benzamides useful as sodium channel blockers

The invention provides a compound of formula: or a salt thereof, wherein the variables R, n, ring A, ring B, R, R, R, R, R, R, R, R, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

The invention provides compounds having the general formula I: (i) and pharmaceutically acceptable salts thereof, wherein the variables R, R, subscript n, ring A, X, L, subscript m, X, ring B, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

This invention is directed to methods of preparing benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.

The invention provides compounds having activity as sodium channel (e.g., NaV1.7) inhibitors that are useful for treating sodium channel-mediated diseases or conditions, such as pain, as well as other diseases and conditions associated with the mediation of sodium channels, and compositions containing such compounds and methods for using such compounds and compositions.

The invention provides novel compounds having the general formula (I) and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X, L, subscript m, X, ring D, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

N-substituted benzamides and methods of use thereof

The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables R, R, subscript n, subscript q, ring A, X, L, subscript m, X, R, R, R, R, R, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

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Surrey, Canada

Sultan Chowdhury