Merck Sharp + Dohme Corp.

Msd International Gmbh

Sulagna Sanyal

David L Sloman

Phieng Siliphaivanh

Craig R Gibeau

Qinglin Pu

Yongxin Han

David James Witter

Kun Liu

Wensheng Yu

Hongjun Zhang

Ping Liu

Michelle R Machacek

Derun Li

Abdelghani Achab

Yongqi Deng

Timothy J Henderson

Michael Hale Reutershan

Xavier Fradera

Jean-Laurent Paparin

David Jonathan Bennett

Yingchun Ye

Houcine Rahali

Chunhui Huang

Indu T Bharathan

Ryan Quiroz

Brett A Hopkins

Sebastian Schneider

Xin Yan

Charles S Yeung

Wenlang Fu

Shuhei Kawamura

David Annunziato Candito

Steven Mark Silverman

Meredeth A Mcgowan

George Madalin Giambasu

Murray Wan

Jonathan M E Hughes

Patrick S Fier

Jonathan D Bennett

Bridget A Becker

Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as IL4I1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for IL4I1-related diseases.

IL4I1 inhibitors and methods of use

Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

Substituted tetrahydroquinolin compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors

The present invention provides a compound of Formula (I) and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.

PRMT5 inhibitors

Growing community of inventors

Belmont, MA, United States of America

Sulagna Sanyal