Sirius Therapeutics, Inc.

Tallac Therapeutics, Inc.

Orchid Chemicals & Pharmaceuticals Limited

R&d-biopharmaceuticals Gmbh

Tollnine, Inc.

Dömling, Alexander

Sukumar Sakamuri

Son Lam

Laxman Eltepu

Curt William Bradshaw

Dingguo Liu

Bryan R Meade

Curt W Bradshaw

Bin Liu

Jaume Pons

Tracy Chia-Chien Kuo

Bang Janet Sim

Ayman Kabakibi

Giuseppe Dello Iacono

Joseph Stock

Edward Hyungsuk Ha

Hong I Wan

Edward HyungSuk Ha

Gopalan Balasubramanian

Shridhar Narayanan

Alexander Dömling

Bernd Henkel

Sivanesan Dharmalingam

Franklin Pooppady Xavier

Jeyamurugan Mookkan

Jeganatha Sivakumar Balasubramanian

Agneeswari Rajalingam

Jayanarayan Kulathingal

Barbara Beck

Katrin Illgen

Sanjay Menon

Gajendra Singh

Alexander Doemling

Immunomodulating polynucleotides are disclosed. The immunomodulating polynucleotides may contain 5-modified uridine, 5-modified cytidine, a total of from 6 to 16 nucleotides, and/or one or more abasic spacers and/or internucleoside phosphotriesters. Also disclosed are conjugates containing a targeting moiety and one or more immunomodulating polynucleotides. The immunomodulating polynucleotides and conjugates may further contain one or more auxiliary moieties. Also disclosed are compositions containing the immunomodulating polynucleotides or the conjugates containing one or more stereochemically enriched internucleoside phosphorothioates. Further disclosed are pharmaceutical compositions containing the immunomodulating polynucleotides or the conjugates and methods of their use.

Immunomodulating polynucleotides, antibody conjugates thereof, and methods of their use

Disclosed are P-stereogenic groups that may be used in the synthesis of compounds including stereochemically enriched P-stereogenic phosphorothioates. P-stereogenic groups may be provided in nucleoside phosphoramidites including a sugar bonded to a nucleobase and to a stereochemically enriched phosphoramidite as well as methods of their use and methods of making them.

Chiral phosphoramidite auxiliaries and methods of their use

Disclosed are polynucleotide constructs having a strand linked to a moiety carrying one or more auxiliary moieties. Also disclosed are polynucleotide constructs interrupted with a sugar analogue, and polynucleotide constructs with stereochemical{circumflex over ( )} enriched phosphorothioates. The polynucleotide constructs may be provided as hybridized polynucleotide constructs. Also featured are methods of delivery a polynucleotide construct to a cell and methods of reducing the expression of a protein in a cell by contacting the cell with the disclosed polynucleotide construct or hybridized polynucleotide construct.

Polynucleotide constructs

The present disclosure provides for antibody-oligonucleotide conjugates, methods of preparation thereof, and methods of use thereof. Also provided are related compounds, compositions and kits.

Transglutaminase-mediated conjugation

Disclosed are chiral phosphoramidite auxiliary compositions for diastereoselective synthesis of stereochemically enriched oligonucleotides, and nucleoside phosphoramidite compounds comprising the same. Exemplary structures of the chiral phosphoramidite auxiliary compositions include Formulas (IA) and (IB). 

Described are novel compounds of the Formula (I), their derivatives, analogs, tautomeric forms, regioisomers, stereoisomers, polymorphs, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. These compounds are effective in lowering blood glucose, serum insulin, free fatty acids, cholesterol, triglyceride levels; treatment of obesity, inflammation, autoimmune diseases such as multiple sclerosis, rheumatoid arthritis; treatment and/or prophylaxis of type II diabetes. These compounds are more particularly dipeptidyl peptidase (DPP IV) inhibitors. 

Dipeptidyl peptidase IV inhibitors

The invention relates to tubulysin derivatives of general formula (II), said derivatives having a cytostatic effect. 

Tubulysin analogues

Growing community of inventors

San Diego, CA, United States of America

Sukumar Sakamuri