Lg Life Sciences, Limited

Suk Kyoon Yoon

Bong Chan Kim

Ho Jun Kim

Sun Hwa Lee

Koo Lee

Hee Dong Park

Tae Hun Kim

Cheol Won Park

Won Hyuk Jung

Aeri Kim

Han Joo Maeng

Sung Ji Kim

Kyung Ha Chung

Jae Chul Lee

Kwan Hyung Cho

The present invention provides a method of predicting a food-drug interaction in vivo, in the case of an orally administered drug interactive with digestive enzymes in the gastrointestinal tract, by measuring the activity of the drug to the digestive enzymes in vitro, which is based on the fact that the ingestion of foods causes the absorption of drug in vivo to decrease due to the above interaction between a drug and digestive enzymes. The present invention further provides methods of minimizing the change of absorption in vivo caused by the ingestion of foods by reducing the action of digestive enzymes, for example, introduction of prodrugs, modification of the chemical structure of drug, design of drug formulation, etc.

Method of predicting drug-food interaction

The present invention provides a novel process for preparing a compound represented by the above formula 7, which is an important intermediate for an oral thrombin inhibitor, by one-pot reaction. In accordance with the present invention, the above intermediate for the thrombin inhibitor may be obtained in a high yield.

Process for preparing 5-aminomethyl-2-thiophenecarbonitrile HCl by one-pot reaction

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Taejeon, South Korea

Suk Kyoon Yoon